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APC Anti-Mouse CD200 Antibody [OX-90] (AGEL2476)

SKU:
AGEL2476
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Applications:
FCM
Reactivity:
Mouse
Host Species:
Rat
Isotype:
Rat IgG2a, κ
Clone:
OX-90
Conjugation:
APC
€189 - €459
Frequently bought together:

Description

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APC Anti-Mouse CD200 Antibody [OX-90]

The Mouse CD200 Monoclonal Antibody (Clone: OX-90, Catalog Number: AGEL2476) from Assay Genie is a high-quality research tool specifically designed for the detection and analysis of CD200, a cell surface glycoprotein involved in immune regulation. This antibody, produced using hybridoma technology, exhibits high specificity and sensitivity for mouse samples and has been validated for use in various experimental applications.CD200, also known as OX-2, is a potent immunoregulatory molecule that plays a pivotal role in maintaining immune tolerance and preventing excessive immune responses. Its interaction with its receptor, CD200R, helps in suppressing inflammation and modulating immune cell activity. Research indicates that dysregulation of the CD200-CD200R axis is associated with autoimmune diseases, neuroinflammatory disorders, and other immune-related conditions.The Mouse CD200 Monoclonal Antibody (Clone: OX-90) provides researchers with a reliable tool to study the expression and function of CD200 in different cell types and tissues, making it particularly valuable for investigations in immunology, neurobiology, and inflammation-related research.

By targeting CD200, this antibody enables researchers to deepen their understanding of immune regulation mechanisms and explore potential therapeutic strategies for immune-mediated diseases.In summary, the Mouse CD200 Monoclonal Antibody (Clone: OX-90) is an essential reagent for studies focusing on the role of CD200 in immune modulation, immunotherapy, and the pathogenesis of various diseases. With its high specificity and robust performance, this antibody serves as a valuable asset in advancing research efforts aimed at unraveling the complex interplay between the immune system and disease processes.

Product Title:APC Anti-Mouse CD200 Antibody [OX-90]
SKU:AGEL2476
Size:25µg, 100µg
Clone No:OX-90
Synonyms:OX-2 membrane glycoprotein;OX-2; MRC;
Host Species:Rat
Reactivity:Mouse
Application:FCM
Isotype:Rat IgG2a, κ
Isotype Control:APC Rat IgG2a, κ Isotype Control[2A3]
Form:Liquid
Conjugation:APC
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use. We suggest each investigator should titrate the reagent to obtain optimal results [The recommended concentration is 0.1-1 μg/106 cells in 100 μL volume].
Spectrum:Spectrum Image
Swissprot:O54901
Gene ID:4345
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD200 (OX-2 antigen) is a type-1 membrane glycoprotein containing two extracellular Ig-like domains. CD200 a highly conserved type I membrane glycoprotein that is expressed on a variety of cell types including thymocytes, some T cells, endothelial and follicular dendritc cells, B cells, and brain tissue (neurons); but not on NK cells, granulocytes, monocytes, or macrophages. CD200 costimulates T cell proliferation. It may regulate myeloid cell activity in a variety of tissues. CD200 is the ligand for CD200 receptor (CD200R). The CD200 Receptor is restricted to myeloid cells, and it is believed that its engagement with CD200 results in inhibition and/or downregulation of myeloid cell activity. Blocking of CD200/CD200R interactions decreases myeloid cell inhibitory thresholds which results in enhanced immune activation.

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