null

APC Anti-Mouse CD200 Antibody [OX-90] (AGEL2475)

SKU:
AGEL2475
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Applications:
FCM
Reactivity:
Mouse
Host Species:
Rat
Isotype:
Rat IgG2a, κ
Clone:
OX-90
Conjugation:
APC
€209 - €499
Frequently bought together:

Description

system_update_altDatasheetsystem_update_altMSDS

APC Anti-Mouse CD200 Antibody [OX-90]

The APC Anti-Mouse CD200 Antibody (OX-90) is a highly specific monoclonal antibody designed for the detection of CD200, a cell surface glycoprotein that plays a key role in immune regulation. This antibody, tested and validated for use in flow cytometry and immunohistochemistry applications, binds specifically to mouse CD200, enabling precise detection and analysis in various tissues and cell types.CD200, also known as OX-2, functions as a potent immunoregulatory molecule by interacting with its receptor, CD200R, to suppress immune responses and maintain immune tolerance. Its significance in immune modulation makes it a crucial target for research related to immunology, autoimmune diseases, and inflammatory conditions.

Understanding the role of CD200 in immune regulation is essential for developing targeted therapies for diseases where immune dysregulation is a key factor.Whether investigating immune responses in mouse models, exploring mechanisms of immune tolerance, or studying the role of CD200 in specific pathologies, the APC Anti-Mouse CD200 Antibody (OX-90) provides researchers with a reliable tool for precise and accurate detection of CD200 expression, facilitating in-depth insights into immune regulation and potential therapeutic targets.

Product Title:APC Anti-Mouse CD200 Antibody [OX-90]
SKU:AGEL2475
Size:50 Tests, 100 Tests, 200 Tests
Clone No:OX-90
Synonyms:OX-2 membrane glycoprotein;OX-2; MRC;
Host Species:Rat
Reactivity:Mouse
Application:FCM
Isotype:Rat IgG2a, κ
Isotype Control:APC Rat IgG2a, κ Isotype Control[2A3]
Form:Liquid
Conjugation:APC
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:Spectrum Image
Swissprot:O54901
Gene ID:4345
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD200 (OX-2 antigen) is a type-1 membrane glycoprotein containing two extracellular Ig-like domains. CD200 a highly conserved type I membrane glycoprotein that is expressed on a variety of cell types including thymocytes, some T cells, endothelial and follicular dendritc cells, B cells, and brain tissue (neurons); but not on NK cells, granulocytes, monocytes, or macrophages. CD200 costimulates T cell proliferation. It may regulate myeloid cell activity in a variety of tissues. CD200 is the ligand for CD200 receptor (CD200R). The CD200 Receptor is restricted to myeloid cells, and it is believed that its engagement with CD200 results in inhibition and/or downregulation of myeloid cell activity. Blocking of CD200/CD200R interactions decreases myeloid cell inhibitory thresholds which results in enhanced immune activation.

Related Products