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APC Anti-Mouse CD163 Antibody [S15049F] (AGEL3397)

SKU:
AGEL3397
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Applications:
FCM
Reactivity:
Mouse
Host Species:
Rat
Isotype:
Rat IgG2a, k
Clone:
S15049F
Conjugation:
APC
€239 - €619
Frequently bought together:

Description

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APC Anti-Mouse CD163 Antibody [S15049F]

The APC Anti-Mouse CD163 Antibody (S15049F-AGEL3397) is a powerful tool for researchers investigating the role of CD163, a key protein associated with immune regulation and inflammation. This antibody, specifically designed for use in mouse samples, is highly selective and validated for use in flow cytometry applications. By targeting the CD163 protein, this antibody allows for accurate detection and analysis in various immune cell populations, enabling detailed studies in immunology and related fields.CD163, a cell surface receptor primarily expressed on macrophages and monocytes, plays a crucial role in regulating immune responses and inflammation. It is involved in processes such as phagocytosis and cytokine production, making it a significant player in the immune system's function.

Research involving CD163 is important for understanding diseases like cancer, inflammatory disorders, and infections, as well as for developing targeted therapies that can modulate immune responses effectively.With its high specificity and reliability, the APC Anti-Mouse CD163 Antibody (S15049F-AGEL3397) is a valuable tool for researchers looking to delve into the intricate mechanisms of immune regulation and inflammation in the context of various diseases. Its compatibility with flow cytometry applications ensures accurate and reproducible results, making it an essential component for studies aimed at unraveling the complexities of the immune system.

Product Title:APC Anti-Mouse CD163 Antibody [S15049F]
SKU:AGEL3397
Size:25µg, 100µg
Clone No:S15049F
Synonyms:M130; MM130; SCARI1;
Host Species:Rat
Reactivity:Mouse
Application:FCM
Isotype:Rat IgG2a, κ
Isotype Control:APC Rat IgG2a, κ Isotype Control[2A3]
Form:Liquid
Conjugation:APC
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use. We suggest each investigator should titrate the reagent to obtain optimal results [The recommended concentration is 0.1-1 μg/106 cells in 100 μL volume].
Spectrum:Spectrum Image
Swissprot:Q2VLH6
Gene ID:93671
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD163 is a member of the group B scavenger receptor cysteine-rich superfamily, also known as GHI/61, M130, RM3/1, p155, hemoglobin-haptoglobin complex receptor, or macrophage-associated antigen. It is a 134 kD (non-reduced)/155 kD (reduced) glycoprotein primarily expressed on macrophages, Kupffer cells, monocytes, a subset of dendritic cells, and a subset of hematopoietic stem/progenitor cells. CD163 binds to haptoglobin-hemoglobin complex and TWEAK, and plays a role in clearing hemoglobin and regulating cytokine production by macrophages. Membrane CD163 can be cleaved by metalloproteinases (MMP), resulting in a soluble form. Elevated serum level of sCD163 has been implicated in many kinds of inflammatory diseases.

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