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APC Anti-Mouse CD105 Antibody [MJ7/18] (AGEL2472)

SKU:
AGEL2472
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Applications:
FCM
Reactivity:
Mouse
Host Species:
Rat
Isotype:
Rat IgG2a, κ
Clone:
MJ7/18
Conjugation:
APC
€219 - €529

Description

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APC Anti-Mouse CD105 Antibody [MJ7/18]

The APC Anti-Mouse CD105 Antibody (MJ7/18) is a valuable tool for researchers studying the CD105 protein, also known as endoglin, which plays a crucial role in angiogenesis and vascular development. This antibody, specifically designed for mouse samples, is purified from ascites fluid and is ideal for flow cytometry and immunohistochemistry applications. By targeting the CD105 protein, researchers can investigate its expression and function in various mouse tissues, providing insights into processes such as tumor growth, wound healing, and cardiovascular development.CD105 is a transmembrane glycoprotein that is highly expressed on endothelial cells and is involved in TGF-β signaling pathways, influencing cell proliferation, migration, and differentiation.

Its upregulation is associated with conditions like cancer, fibrosis, and vascular disorders, making it a promising therapeutic target for anti-angiogenic strategies. The APC Anti-Mouse CD105 Antibody (MJ7/18) enables precise detection and analysis of CD105 expression patterns, supporting research efforts to unravel the molecular mechanisms underlying angiogenesis and vascular pathology in various disease contexts.

Product Title:APC Anti-Mouse CD105 Antibody [MJ7/18]
SKU:AGEL2472
Size:50 Tests, 100 Tests, 200 Tests
Clone No:MJ7/18
Synonyms:Endoglin;END;Eng;
Host Species:Rat
Reactivity:Mouse
Application:FCM
Isotype:Rat IgG2a, κ
Isotype Control:APC Rat IgG2a, κ Isotype Control[2A3]
Form:Liquid
Conjugation:APC
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:Spectrum Image
Swissprot:Q63961
Gene ID:13805
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD105 is a 90 kD homodimeric type I integral membrane glycoprotein, also known as endoglin. It is expressed on endothelial cells (especially on angiogenic endothelial cells) and upregulated by hypoxia, activated monocytes, macrophages, bone marrow stromal cells, and some cytotrophoblasts. CD105 is a receptor for TGF-β1, TGF-β3 and modulates TGF-β signaling by interacting with TGF-β receptors I and/or II. CD105 also binds other growth factors such as actvin A, BMP-2, and BMP-7. CD105 has been show to be a useful marker for identifying proliferating endothelium involved in tumor angiogenesis and can be used for tumor imaging and prognosis, and has therapeutic potential for some solid tumors and other angiogenic diseases.

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