APC Anti-Human CD279/PD-1 Antibody [EH12.2H7] (AGEL2724)
- SKU:
- AGEL2724
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Applications:
- FCM
- Reactivity:
- Human
- Host Species:
- Mouse
- Isotype:
- Mouse IgG1, κ
- Clone:
- EH12.2H7
- Conjugation:
- APC
Frequently bought together:
Description
Product Title: | APC Anti-Human CD279/PD-1 Antibody [EH12.2H7] |
SKU: | AGEL2724 |
Size: | 20 Tests, 100 Tests, 200 Tests |
Clone No: | EH12.2H7 |
Synonyms: | PDCD1;PD1;Protein PD-1;hPD-1; |
Host Species: | Mouse |
Reactivity: | Human |
Application: | FCM |
Isotype: | Mouse IgG1, κ |
Isotype Control: | APC Mouse IgG1, κ Isotype Control[MOPC-21] |
Form: | Liquid |
Conjugation: | APC |
Recommended Use: | Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use. |
Spectrum: |
Swissprot: | Q15116 |
Gene ID: | 5133 |
Storage Buffer: | Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant. |
Stability & Storage: | Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase. |
Background: | Programmed cell death 1 (PD-1), also known as CD279, is a 55 kD member of the immunoglobulin superfamily. CD279 contains the immunoreceptor tyrosine-based inhibitory motif (ITIM) in the cytoplasmic region and plays a key role in peripheral tolerance and autoimmune disease. CD279 is expressed predominantly on activated T cells, B cells, and myeloid cells. PD-L1 and PD-L2 are ligands of CD279 (PD-1) and are members of the B7 gene family. Evidence suggests overlapping functions for these two PD-1 ligands and their constitutive expression on some normal tissues and upregulation on activated antigen-presenting cells. Interaction of CD279 ligands results in inhibition of T cell proliferation and cytokine secretion. |