APBB1 Rabbit Polyclonal Antibody (CAB1944)
- SKU:
- CAB1944
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Death
Frequently bought together:
Description
Product Name: | APBB1 Rabbit Polyclonal Antibody |
SKU: | CAB1944 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 359-708 of human APBB1 (NP_663722.1). |
Sequence: | PPRN TNPG IKCF AVRS LGWV EMTE EELA PGRS SVAV NNCI RQLS YHKN NLHD PMSG GWGE GKDL LLQL EDET LKLV EPQS QALL HAQP IISI RVWG VGRD SGRD FAYV ARDK LTQM LKCH VFRC EAPA KNIA TSLH EICS KIMA ERRN ARCL VNGL SLDH SKLV DVPF QVEF PAPK NELV QKFQ VYYL GNVP VAKP VGVD VING ALES VLSS SSRE QWTP SHVS VAPA TLTI LHQQ TEAV LGEC RVRF LSFL AVGR DVHT FAFI MAAG PASF CCHM FWCE PNAA SLSE AVQA ACML RYQK CLDA RSQA STSC LPAP PAES VARR VGWT VRRG VQSL WGSL KPKR LGAH TP |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:50 - 1:200 |
Synonyms: | RIR; FE65; MGC:9072; APBB1 |
Positive Sample: | Raji,Lovo,BT-474,A-549,Mouse brain,Mouse heart,Mouse lung,Mouse spinal cord |
Conjugate: | Unconjugated |
Cellular Localization: | Cell membrane, Cell projection, Cytoplasm, Nucleus, Nucleus speckle, growth cone. |
Calculated MW: | 77kDa |
Observed MW: | 63kDa |
The protein encoded by this gene is a member of the Fe65 protein family. It is an adaptor protein localized in the nucleus. It interacts with the Alzheimer's disease amyloid precursor protein (APP), transcription factor CP2/LSF/LBP1 and the low-density lipoprotein receptor-related protein. APP functions as a cytosolic anchoring site that can prevent the gene product's nuclear translocation. This encoded protein could play an important role in the pathogenesis of Alzheimer's disease. It is thought to regulate transcription. Also it is observed to block cell cycle progression by downregulating thymidylate synthase expression. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene.
Purification Method: | Affinity purification |
Gene ID: | 322 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |