The AP4M1 Polyclonal Antibody (PAC00773) is a valuable tool for researchers studying the AP4M1 protein, a key component of the Adaptor Protein Complex 4 involved in intracellular protein trafficking. This antibody, generated in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By targeting the AP4M1 protein, this antibody enables researchers to detect and analyze its expression in various cell types, making it ideal for investigations in cell biology and molecular biology.AP4M1 plays a crucial role in mediating the transport of cargo proteins between different cellular compartments, making it an essential player in maintaining cellular homeostasis.
Dysregulation of AP4M1 function has been linked to various human diseases, including neurological disorders and cancer. Research on AP4M1 is important for understanding the mechanisms underlying these diseases and developing potential therapeutic interventions targeting this protein.Overall, the AP4M1 Polyclonal Antibody is a reliable tool for researchers interested in studying the function and regulation of AP4M1 in normal cellular processes and disease conditions. Its specificity and sensitivity make it a valuable asset for advancing research in the fields of cell biology, molecular biology, and biomedicine.
adaptor-related protein complex 4, mu 1 subunit;AP4M1;MU-4;MU-ARP2 ;
UniProt Protein Function:
AP4M1: Subunit of novel type of clathrin- or non-clathrin- associated protein coat involved in targeting proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. Defects in AP4M1 are the cause of cerebral palsy spastic quadriplegic type 3 (CPSQ3). A non-progressive disorder of movement and/or posture resulting from defects in the developing central nervous system. Affected individuals present postnatally with early infantile hypotonia, delayed psychomotor development, strabismus, lack of independent walking and severe mental retardation. They develop progressive spasticity of all limbs with generalized hypertonia, hyperreflexia, and extensor plantar responses by the end of the first year of life. Speech is absent or limited. Pseudobulbar signs, such as drooling, stereotypic laughter, and exaggerated jaw jerk, are part of the clinical picture. Belongs to the adaptor complexes medium subunit family.Protein type: Adaptor/scaffoldChromosomal Location of Human Ortholog: 7q22.1Cellular Component: AP-type membrane coat adaptor complex; Golgi trans cisterna; trans-Golgi network; trans-Golgi network membraneMolecular Function: protein binding; transporter activityBiological Process: Golgi to endosome transport; intracellular protein transport; vesicle-mediated transportDisease: Spastic Paraplegia 50, Autosomal Recessive
UniProt Protein Details:
NCBI Summary:
This gene encodes a subunit of the heterotetrameric AP-4 complex. The encoded protein belongs to the adaptor complexes medium subunits family. This AP-4 complex is involved in the recognition and sorting of cargo proteins with tyrosine-based motifs from the trans-golgi network to the endosomal-lysosomal system. [provided by RefSeq, Jul 2008]
AP-4 adaptor complex mu subunit; Adaptor-related protein complex 4 subunit mu-1; Mu subunit of AP-4; Mu-adaptin-related protein 2; mu-ARP2; Mu4-adaptin; mu4
