The AP3D1 Polyclonal Antibody (CAB13058) is a valuable research tool designed for studying AP-3 complex subunit delta-1 (AP3D1), a key protein involved in intracellular trafficking and vesicle formation. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By specifically binding to AP3D1, researchers can accurately detect and analyze this important protein in a variety of cell types, making it an essential tool for studies in cell biology and molecular biology.AP3D1 is a crucial component of the AP-3 protein complex, which plays a critical role in sorting cargo proteins for delivery to lysosomes and related organelles.
Dysregulation of AP3D1 function has been linked to various human diseases, including immune deficiencies and neurological disorders. Investigating the role of AP3D1 in intracellular trafficking pathways is essential for understanding disease mechanisms and developing targeted therapies.Overall, the AP3D1 Polyclonal Antibody offers researchers a reliable and specific tool for investigating the function and regulation of AP3D1 in cellular processes, providing valuable insights into disease pathogenesis and potential therapeutic strategies.
Product Name:
AP3D1 Rabbit Polyclonal Antibody
SKU:
CAB13058
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 520-700 of human AP3D1 (NP_003929.4).
The protein encoded by this gene is a subunit of the AP3 adaptor-like complex, which is not clathrin-associated, but is associated with the golgi region, as well as more peripheral structures. The AP-3 complex facilitates the budding of vesicles from the golgi membrane, and may be directly involved in trafficking to lysosomes. This subunit is implicated in intracellular biogenesis and trafficking of pigment granules, and possibly platelet dense granules and neurotransmitter vesicles. Defects in this gene are a cause of a new type of Hermansky-Pudlak syndrome.
Purification Method:
Affinity purification
Gene ID:
8943
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using AP3D1 Rabbit pAb (CAB13058) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
