The AP2S1 Polyclonal Antibody (CAB12270) is a valuable tool for researchers studying AP2S1, a key component of the AP-2 complex involved in clathrin-mediated endocytosis. This antibody, generated in rabbits, demonstrates high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to the AP2S1 protein, this antibody allows for the detection and analysis of AP2S1 in various cell types, making it an ideal choice for studies in cell biology, signal transduction, and membrane trafficking.AP2S1 plays a crucial role in regulating the internalization of cell surface receptors and the transport of cargo proteins within cells.
Dysfunction of the AP-2 complex, including AP2S1, has been implicated in various diseases such as cancer, neurodegenerative disorders, and infectious diseases. Therefore, understanding the function and regulation of AP2S1 is essential for uncovering potential therapeutic targets for these conditions.Overall, the AP2S1 Polyclonal Antibody (CAB12270) provides researchers with a reliable tool for investigating the role of AP2S1 in cellular processes and disease pathogenesis, ultimately contributing to advancements in biomedical research and drug discovery efforts.
Product Name:
AP2S1 Rabbit Polyclonal Antibody
SKU:
CAB12270
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-142 of human AP2S1 (NP_004060.2).
One of two major clathrin-associated adaptor complexes, AP-2, is a heterotetramer which is associated with the plasma membrane. This complex is composed of two large chains, a medium chain, and a small chain. This gene encodes the small chain of this complex. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
1175
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using AP2S1 Rabbit pAb (CAB12270) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 20s.
