The AP2M1 Polyclonal Antibody (CAB2492) is a valuable tool for researchers studying AP2M1, a key protein involved in clathrin-mediated endocytosis. This antibody, raised in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By binding to the AP2M1 protein, it allows for the detection and analysis of AP2M1 levels in various cell types, making it ideal for studies in cell biology and vesicle trafficking.AP2M1 plays a crucial role in the internalization of cell surface receptors and the sorting of cargo proteins in the endocytic pathway.
Dysregulation of AP2M1 function has been implicated in various diseases, including cancer and neurodegenerative disorders. Research into AP2M1 can provide insights into the mechanisms of endocytosis and potential therapeutic targets for these conditions.By using the AP2M1 Polyclonal Antibody, researchers can further their understanding of the role of AP2M1 in cellular processes and disease development, ultimately contributing to advancements in biomedical research and drug discovery.
Product Name:
AP2M1 Rabbit Polyclonal Antibody
SKU:
CAB2492
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 134-433 of human AP2M1 (NP_001020376.1).
This gene encodes a subunit of the heterotetrameric coat assembly protein complex 2 (AP2), which belongs to the adaptor complexes medium subunits family. The encoded protein is required for the activity of a vacuolar ATPase, which is responsible for proton pumping occurring in the acidification of endosomes and lysosomes. The encoded protein may also play an important role in regulating the intracellular trafficking and function of CTLA-4 protein. Three transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
1173
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using AP2M1 Rabbit pAb (CAB2492) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.
