AP1S3 Antibody (PACO24952)
- SKU:
- PACO24952
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
AP1S3 Antibody (PACO24952)
The AP1S3 Polyclonal Antibody (PAC024952) is a valuable tool for researchers studying the AP1S3 protein and its role in intracellular transport pathways. The antibody, derived from rabbit hosts, exhibits high reactivity towards human samples and has been rigorously validated for Western blot applications. By binding specifically to the AP1S3 protein, this antibody allows for accurate detection and evaluation in a variety of cell types, making it an essential component for investigations in cell biology and molecular biology.AP1S3 is a subunit of the adaptor protein complex 1 (AP-1), which plays a crucial role in sorting and trafficking proteins within the cell.
Dysregulation of AP-1 has been implicated in various diseases, including neurodevelopmental disorders and cancer. Therefore, understanding the function and regulation of AP1S3 is essential for uncovering potential therapeutic targets and developing treatments for these conditions.By utilizing the AP1S3 Polyclonal Antibody (PAC024952), researchers can delve deeper into the mechanisms of intracellular transport and protein sorting, leading to advancements in our understanding of cellular processes and their implications in disease pathology. This antibody serves as a valuable tool in the quest for novel therapeutic strategies targeting AP1S3-related pathways.
| Antibody Name: | AP1S3 Antibody (PACO24952) |
| Antibody SKU: | PACO24952 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:1000-1:5000 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human AP-1 complex subunit sigma-3 protein (1-104AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot All lanes: AP1S3 antibody at 2µg/ml + A549 whole cell lysate Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 19, 20, 13 kDa Observed band size: 19 kDa . |
| Background: | Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. |
| Synonyms: | AP-1 complex subunit sigma-3 (Adaptor protein complex AP-1 subunit sigma-1C) (Adaptor-related protein complex 1 subunit sigma-1C) (Clathrin assembly protein complex 1 sigma-1C small chain) (Golgi adaptor HA1/AP1 adaptin sigma-1C subunit) (Sigma 1C subunit of AP-1 clathrin) (Sigma-adaptin 1C) (Sigma1C-adaptin), AP1S3 |
| UniProt Protein Function: | AP1S3: Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. Belongs to the adaptor complexes small subunit family. 4 isoforms of the human protein are produced by alternative splicing.Protein type: Vesicle; Adaptor/scaffoldChromosomal Location of Human Ortholog: 2q36.1Cellular Component: coated pit; cytoplasmic vesicle membrane; cytosol; Golgi membrane; lysosomal membrane; membrane coat; trans-Golgi network membraneMolecular Function: protein binding; protein transporter activityBiological Process: antigen processing and presentation of exogenous peptide antigen via MHC class II; post-Golgi vesicle-mediated transport; protein targeting; regulation of defense response to virus by virus; viral reproductionDisease: Psoriasis 15, Pustular, Susceptibility To |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a member of the adaptor-related protein complex 1, sigma subunit genes. The encoded protein is a component of adaptor protein complex 1 (AP-1), one of the AP complexes involved in claathrin-mediated vesicular transport from the Golgi or endosomes. Disruption of the pathway for display of HIV-1 antigens, which prevents recognition of the virus by cytotoxic T cells, has been shown to involve the AP-1 complex (PMID: 15569716). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014] |
| UniProt Code: | Q96PC3 |
| NCBI GenInfo Identifier: | 88703051 |
| NCBI Gene ID: | 130340 |
| NCBI Accession: | NP_001034658.1 |
| UniProt Secondary Accession: | Q96PC3,Q8WTY1, Q96DD1, B4DQZ1 |
| UniProt Related Accession: | Q96PC3 |
| Molecular Weight: | 12,655 Da |
| NCBI Full Name: | AP-1 complex subunit sigma-3 |
| NCBI Synonym Full Names: | adaptor related protein complex 1 sigma 3 subunit |
| NCBI Official Symbol: | AP1S3Â Â |
| NCBI Official Synonym Symbols: | PSORS15Â Â |
| NCBI Protein Information: | AP-1 complex subunit sigma-3 |
| UniProt Protein Name: | AP-1 complex subunit sigma-3 |
| UniProt Synonym Protein Names: | Adaptor protein complex AP-1 subunit sigma-1C; Adaptor-related protein complex 1 subunit sigma-1C; Clathrin assembly protein complex 1 sigma-1C small chain; Golgi adaptor HA1/AP1 adaptin sigma-1C subunit; Sigma 1C subunit of AP-1 clathrin; Sigma-adaptin 1C; Sigma1C-adaptin |
| Protein Family: | AP-1 complex |
| UniProt Gene Name: | AP1S3Â Â |
| UniProt Entry Name: | AP1S3_HUMAN |
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