The AP1B1 Polyclonal Antibody (CAB16304) is a valuable tool for researchers studying AP1B1, a key protein involved in protein transport and sorting within cells. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blotting applications. By binding specifically to the AP1B1 protein, this antibody enables precise detection and analysis in a variety of cell types, making it an essential reagent for investigations in cell biology and molecular research.AP1B1 is a crucial component of the adaptor protein complex 1 (AP-1), which plays a critical role in the sorting of proteins to their proper destinations within the cell.
Dysregulation of AP1B1 function has been implicated in various diseases, including metabolic disorders and neurological conditions. By studying the function and regulation of AP1B1, researchers can gain insights into cellular processes and potential therapeutic targets for these disorders. The AP1B1 Polyclonal Antibody is a reliable tool for advancing our understanding of AP1B1 and its role in cellular physiology and disease pathology.
Product Name:
AP1B1 Rabbit Polyclonal Antibody
SKU:
CAB16304
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 700-800 of human AP1B1 (NP_001118.3).
Adaptor protein complex 1 is found at the cytoplasmic face of coated vesicles located at the Golgi complex, where it mediates both the recruitment of clathrin to the membrane and the recognition of sorting signals within the cytosolic tails of transmembrane receptors. This complex is a heterotetramer composed of two large, one medium, and one small adaptin subunit. The protein encoded by this gene serves as one of the large subunits of this complex and is a member of the adaptin protein family. This gene is a candidate meningioma gene. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
162
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using AP1B1 Rabbit pAb (CAB16304) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 5min.
