The AOX1A Polyclonal Antibody (PAC062047) is a valuable tool for researchers studying the AOX1A protein, an important player in oxidative stress response and detoxification pathways. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By specifically binding to the AOX1A protein, this antibody enables accurate detection and analysis in a variety of cell types, making it an excellent choice for investigations in oxidative stress, detoxification mechanisms, and related areas of study.
AOX1A is a key enzyme involved in the metabolism of xenobiotics and reactive oxygen species, playing a crucial role in cellular defense against oxidative damage. Its involvement in detoxification processes and maintenance of redox balance makes AOX1A a promising target for research in fields such as toxicology, pharmacology, and environmental health. Understanding the function and regulation of AOX1A is essential for developing potential strategies to enhance cellular defense mechanisms and mitigate oxidative stress-related conditions.
Antibody Name:
AOX1A Antibody (PACO62047)
Antibody SKU:
PACO62047
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:2000-1:10000, WB:1:500-1:2000
Species Reactivity:
Arabidopsis thaliana
Immunogen:
Recombinant Arabidopsis thaliana Ubiquinol oxidase 1a, mitochondrial protein (63-178AA)
Western Blot. Positive WB detected in: Arabidopsis thaliana leaf tissue, Solanum lycopersicum leaf tissue, Glycine max leaf tissue, Solanum tuberosum leaf tissue. All lanes: AOX1A antibody at 1:1500. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 40 kDa. Observed band size: 40 kDa.
Background:
Catalyzes the cyanide-resistant oxidation of ubiquinol and the reduction of molecular oxygen to water, but does not translocate protons and consequently is not linked to oxidative phosphorylation. Increases respiration when the cytochrome respiratory pathway is restricted, or in response to low temperatures.
Catalyzes the cyanide-resistant oxidation of ubiquinol and the reduction of molecular oxygen to water, but does not translocate protons and consequently is not linked to oxidative phosphorylation. Increases respiration when the cytochrome respiratory pathway is restricted, or in response to low temperatures.
UniProt Protein Details:
NCBI Summary:
Encodes AOX1a, an isoform of alternative oxidase that is expressed in rosettes, flowers, and root. The alternative oxidase of plant mitochondria transfers electrons from the ubiquinone pool to oxygen without energy conservations. It is regulated through transcriptional control and by pyruvate. Plays a role in shoot acclimation to low temperature. Also is capable of ameliorating reactive oxygen species production when the cytochrome pathway is inhibited. AOX1a also functions as a marker for mitochondrial retrograde response.
