The ANXA8 Polyclonal Antibody (PAC014043) offered by AssayGenie is specifically designed for research involving ANXA8, a key protein involved in various cellular processes. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications.ANXA8, also known as Annexin A8, is a calcium-dependent phospholipid binding protein that plays a crucial role in intracellular signaling pathways and membrane dynamics. It is involved in processes such as cell migration, apoptosis, and inflammation, making it a key player in various biological processes.Researchers studying cell biology, signal transduction, and membrane dynamics will find the ANXA8 Polyclonal Antibody to be a valuable tool in their experiments.
By targeting the ANXA8 protein, this antibody enables the detection and analysis of ANXA8 in different cell types, providing insights into its functions and regulatory mechanisms.With its high specificity and sensitivity, the ANXA8 Polyclonal Antibody is ideal for studies in molecular biology, biochemistry, and cell physiology. It is a valuable resource for investigating the role of ANXA8 in various cellular processes and its potential implications in diseases such as cancer, cardiovascular disorders, and neurodegenerative conditions.
The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using PACO14043(ANXA8 Antibody) at dilution 1/35, on the right is treated with fusion protein. (Original magnification: x200).
Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane: A549 cells, Primary antibody: PACO14043(ANXA8 Antibody) at dilution 1/300, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 minutes.
The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using PACO14043(ANXA8 Antibody) at dilution 1/35, on the right is treated with fusion protein. (Original magnification: x200).
Background:
This gene encodes a member of the annexin family of evolutionarily conserved Ca2+ and phospholipid binding proteins. The encoded protein may function as an an anticoagulant that indirectly inhibits the thromboplastin-specific complex. Overexpression of this gene has been associated with acute myelocytic leukemia. A highly similar duplicated copy of this gene is found in close proximity on the long arm of chromosome 10.
Synonyms:
annexin A8
UniProt Protein Function:
ANXA8: This protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade. Belongs to the annexin family.Chromosomal Location of Human Ortholog: 10q11.22Cellular Component: late endosome membrane; plasma membrane; cytosolMolecular Function: actin filament binding; phosphatidylinositol-4,5-bisphosphate binding; phosphatidylinositol-3,4,5-triphosphate binding; calcium-dependent phospholipid binding; calcium ion binding; phosphatidylinositol-3,4-bisphosphate bindingBiological Process: endosome organization and biogenesis; blood coagulation; endosome transport
UniProt Protein Details:
NCBI Summary:
This gene encodes a member of the annexin family of evolutionarily conserved Ca2+ and phospholipid binding proteins. The encoded protein may function as an an anticoagulant that indirectly inhibits the thromboplastin-specific complex. Overexpression of this gene has been associated with acute myelocytic leukemia. A highly similar duplicated copy of this gene is found in close proximity on the long arm of chromosome 10. [provided by RefSeq, Jul 2008]
