The ANXA8 Polyclonal Antibody (PACO14042) is a valuable tool for researchers studying ANXA8, a protein involved in various cellular processes including cell growth, apoptosis, and inflammation. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding to the ANXA8 protein, this antibody enables accurate detection and analysis in a variety of cell types, making it an essential component for studies in immunology and cancer research.
ANXA8, also known as Annexin A8, plays a crucial role in the regulation of inflammatory responses and cell signaling pathways. Its involvement in these fundamental processes underscores its potential as a therapeutic target for diseases such as cancer, autoimmune disorders, and inflammatory conditions. By delving into the mechanisms of ANXA8 action, researchers can gain insights that may lead to the development of novel treatment strategies that modulate cellular function and combat disease progression.
Antibody Name:
ANXA8 Antibody (PACO14042)
Antibody SKU:
PACO14042
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:5000, IHC:1:25-1:100
Species Reactivity:
Human, Mouse, Rat
Immunogen:
Fusion protein of human ANXA8
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using PACO14042(ANXA8 Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO14042(ANXA8 Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: x200).
Background:
This gene encodes a member of the annexin family of evolutionarily conserved Ca2+ and phospholipid binding proteins. The encoded protein may function as an an anticoagulant that indirectly inhibits the thromboplastin-specific complex. Overexpression of this gene has been associated with acute myelocytic leukemia. A highly similar duplicated copy of this gene is found in close proximity on the long arm of chromosome 10.
Synonyms:
annexin A8
UniProt Protein Function:
ANXA8: This protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade. Belongs to the annexin family.Chromosomal Location of Human Ortholog: 10q11.22Cellular Component: late endosome membrane; plasma membrane; cytosolMolecular Function: actin filament binding; phosphatidylinositol-4,5-bisphosphate binding; phosphatidylinositol-3,4,5-triphosphate binding; calcium-dependent phospholipid binding; calcium ion binding; phosphatidylinositol-3,4-bisphosphate bindingBiological Process: endosome organization and biogenesis; blood coagulation; endosome transport
UniProt Protein Details:
NCBI Summary:
This gene encodes a member of the annexin family of evolutionarily conserved Ca2+ and phospholipid binding proteins. The encoded protein may function as an an anticoagulant that indirectly inhibits the thromboplastin-specific complex. Overexpression of this gene has been associated with acute myelocytic leukemia. A highly similar duplicated copy of this gene is found in close proximity on the long arm of chromosome 10. [provided by RefSeq, Jul 2008]
