Annexin A5/Annexin V Rabbit Polyclonal Antibody (CAB13945)
The ANXA5 Polyclonal Antibody (CAB13945) is a valuable tool for research involving ANXA5, a protein known for its role in apoptosis and the regulation of cell membrane dynamics. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding to the ANXA5 protein, this antibody enables accurate detection and analysis in a variety of cell types, making it an essential component for studies in cell biology, apoptosis, and cancer research.ANXA5, also known as annexin A5, is a calcium-dependent phospholipid-binding protein that plays a crucial role in the regulation of cell death processes.
Its involvement in apoptosis and cell membrane function makes it a key target for research into various diseases, including cancer, cardiovascular disorders, and autoimmune conditions. Investigating the function of ANXA5 can provide insights into mechanisms underlying these diseases and aid in the development of new therapeutic strategies aimed at modulating cell death pathways.
Product Name:
Annexin A5/Annexin V Rabbit Polyclonal Antibody
SKU:
CAB13945
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-320 of human Annexin A5/Annexin V (NP_001145.1).
PP4; ANX5; ENX2; CPB-I; RPRGL3; HEL-S-7; VAC-alph; Annexin A5/Annexin V
Positive Sample:
HepG2,HeLa
Conjugate:
Unconjugated
Cellular Localization:
cytoplasm, cytosol, external side of plasma membrane, extracellular exosome, extracellular region, focal adhesion
Calculated MW:
36kDa
Observed MW:
36kDa
The Annexin 5 gene spans 29 kb containing 13 exons, and encodes a single transcript of approximately 1.6 kb and a protein product with a molecular weight of about 35 kDa.The protein encoded by this gene belongs to the annexin family of calcium-dependent phospholipid binding proteins some of which have been implicated in membrane-related events along exocytotic and endocytotic pathways. Annexin 5 is a phospholipase A2 and protein kinase C inhibitory protein with calcium channel activity and a potential role in cellular signal transduction, inflammation, growth and differentiation. Annexin 5 has also been described as placental anticoagulant protein I, vascular anticoagulant-alpha, endonexin II, lipocortin V, placental protein 4 and anchorin CII. Polymorphisms in this gene have been implicated in various obstetric complications.
Purification Method:
Affinity purification
Gene ID:
308
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of various lysates, using Annexin A5/Annexin V Rabbit pAb (CAB13945) at 1:600 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
