The ANXA2R Polyclonal Antibody (PAC019333) is a valuable tool for researchers studying ANXA2R, a protein involved in various cellular processes such as cell adhesion and signaling. This antibody, raised in rabbits, exhibits high specificity and reactivity with human samples, making it ideal for use in Western blot applications.ANXA2R, also known as Annexin A2 Receptor, plays a crucial role in regulating cell functions such as migration, invasion, and proliferation. Its involvement in these processes makes it a promising target for research in areas such as cancer biology, cell biology, and drug development.
By using the ANXA2R Polyclonal Antibody, researchers can detect and analyze ANXA2R protein levels in different cell types, providing valuable insights into its functions and potential therapeutic implications.Understanding the role of ANXA2R in cellular pathways and disease mechanisms is essential for developing targeted therapies and diagnostic tools for conditions where ANXA2R dysregulation is implicated. The ANXA2R Polyclonal Antibody offers a reliable and specific tool for researchers to advance their studies in this field and contribute to the development of innovative treatments.
Antibody Name:
ANXA2R Antibody (PACO19333)
Antibody SKU:
PACO19333
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:1000-1:2000, IHC:1:25-1:100
Species Reactivity:
Human
Immunogen:
Synthetic peptide of human ANXA2R
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO19333(ANXA2R Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human tonsil tissue using PACO19333(ANXA2R Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
ANXA2R (annexin-2 receptor), also known as AX2R or C5orf39, is a 193 amino acid, protein that is widely expressed and may act as an annexin II receptor on marrow stromal cells to induce osteoclast formation. In addition, ANXA2R is highly expressed in lymphocytes and is also found in resting CD4+ and CD8+ T cells. The gene encoding ANXA2R maps to human chromosome 5, which contains 181 million base pairs and comprises nearly 6% of the human genome. Chromosome 5 is associated with Cockayne syndrome through the ERCC8 gene and familial adenomatous polyposis through the adenomatous polyposis coli (APC) tumor suppressor gene. Treacher Collins syndrome is also chromosome 5-associated and is caused by insertions or deletions within the TCOF1 gene.
Synonyms:
annexin A2 receptor
UniProt Protein Function:
Myb: Transcriptional activator; DNA-binding protein that specifically recognize the sequence 5'-YAAC[GT]G-3'. Plays an important role in the control of proliferation and differentiation of hematopoietic progenitor cells. 6 isoforms of the human protein are produced by alternative splicing.Protein type: Transcription factor; Oncoprotein; DNA-bindingChromosomal Location of Human Ortholog: 6q22-q23Cellular Component: nuclear matrix; cytosolMolecular Function: protein binding; chromatin bindingBiological Process: positive regulation of histone H3-K9 methylation; thymus development; transcription, DNA-dependent; in utero embryonic development; positive regulation of transcription, DNA-dependent; homeostasis of number of cells; positive regulation of histone H3-K4 methylation; negative regulation of transcription from RNA polymerase II promoter; chromatin remodeling; positive regulation of T-helper cell differentiation; regulation of transcription, DNA-dependent; calcium ion transport; B cell differentiation; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; blood coagulation; embryonic gut development; G1/S transition of mitotic cell cycle
