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Anxa1 Antibody (PACO24916)

SKU:
PACO24916
Product Type:
Antibody
Reactivity:
Mouse
Human
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
WB
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
€339
Frequently bought together:

Description

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Anxa1 Antibody (PACO24916)

The ANXA1 Polyclonal Antibody (PAC024916) is a valuable tool for researchers studying the ANXA1 protein, which is involved in inflammation and immune response modulation. This antibody, generated in rabbits, is highly reactive with human samples and is validated for use in various applications, including Western blot analysis. By binding specifically to ANXA1, this antibody enables accurate detection and analysis in different cell types, making it an ideal choice for studies in immunology, inflammation, and cancer research.

ANXA1, also known as Annexin A1, plays a crucial role in the regulation of inflammatory responses and immune cell function. Its involvement in these processes makes it a promising target for investigating diseases such as cancer, autoimmune disorders, and inflammatory conditions. Understanding the function of ANXA1 is essential for developing therapeutic strategies that can modulate immune responses and potentially treat these conditions effectively.

Antibody Name:Anxa1 Antibody (PACO24916)
Antibody SKU:PACO24916
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA, WB
Recommended Dilutions:ELISA:1:2000-1:10000, WB:1:500-1:2000
Species Reactivity:Mouse, Human
Immunogen:Recombinant Mouse Annexin A1 protein (2-346AA)
Form:Liquid
Storage Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Purification Method:>95%, Protein G purified
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Product ImageWestern blot
All lanes: Anxa1 antibody at 12µg/ml
Lane 1: K562 whole cell lysate
Lane 2: Hela whole cell lysate
Lane 3: HepG2 whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 39 kDa
Observed band size: 39 kDa
.
Background:Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis. This protein regulates phospholipase A2 activity. It seems to bind from two to four calcium ions with high affinity.
Synonyms:Annexin A1 (Annexin I) (Annexin-1) (Calpactin II) (Calpactin-2) (Chromobindin-9) (Lipocortin I) (Phospholipase A2 inhibitory protein) (p35), Anxa1, Anx1 Lpc-1 Lpc1
UniProt Protein Function:ANXA1: a calcium/phospholipid-binding protein with which promotes membrane fusion and is involved in endocytosis. Has anti-inflammatory properties and inhibits phospholipase A2 activity. Accumulates on internalized vesicles after EGF-stimulated endocytosis, suggesting that it may be required for a late stage in inward vesiculation. Phosphorylated by PKC, EGFR and Chak1. Phosphorylation results in loss of the inhibitory activity. Annexins are a family of structurally related proteins whose common property is calcium-dependent binding to phospholipids. There are at least ten different annexins in mammalian species. Annexins do not contain signal peptides, yet some annexins (A1, A2 and A5) appear to be secreted in a physiologically regulated fashion.Protein type: Lipid-binding; Calcium-bindingChromosomal Location of Human Ortholog: 9q21.13Cellular Component: extracellular space; mast cell granule; cell surface; focal adhesion; protein complex; basolateral plasma membrane; extracellular region; cornified envelope; cilium; mitochondrial membrane; cytoplasm; plasma membrane; nucleus; vesicle; sarcolemma; endosomeMolecular Function: protein binding, bridging; protein binding; protein homodimerization activity; single-stranded RNA binding; calcium-dependent phospholipid binding; phospholipase A2 inhibitor activity; double-stranded DNA-dependent ATPase activity; phospholipid binding; calcium ion binding; structural molecule activity; calcium-dependent protein binding; helicase activity; single-stranded DNA binding; receptor bindingBiological Process: response to drug; prostate gland development; response to peptide hormone stimulus; positive regulation of neutrophil apoptosis; gliogenesis; positive regulation of vesicle fusion; alpha-beta T cell differentiation; arachidonic acid secretion; neutrophil homeostasis; signal transduction; endocrine pancreas development; response to estradiol stimulus; DNA duplex unwinding; regulation of cell proliferation; keratinocyte differentiation; cell surface receptor linked signal transduction; insulin secretion; DNA strand renaturation; peptide cross-linking; inflammatory response; cell motility; response to X-ray; positive regulation of prostaglandin biosynthetic process; negative regulation of apoptosis
UniProt Protein Details:
NCBI Summary:This gene encodes a membrane-localized protein that binds phospholipids. This protein inhibits phospholipase A2 and has anti-inflammatory activity. Loss of function or expression of this gene has been detected in multiple tumors. [provided by RefSeq, Dec 2014]
UniProt Code:P10107
NCBI GenInfo Identifier:4502101
NCBI Gene ID:301
NCBI Accession:NP_000691.1
UniProt Secondary Accession:P10107
UniProt Related Accession:P10107,P04083
Molecular Weight:Calculated MW: 38714
NCBI Full Name:annexin A1
NCBI Synonym Full Names:annexin A1
NCBI Official Symbol:ANXA1  
NCBI Official Synonym Symbols:ANX1; LPC1  
NCBI Protein Information:annexin A1
UniProt Protein Name:Annexin A1
UniProt Synonym Protein Names:Annexin I; Annexin-1; Calpactin II; Calpactin-2; Chromobindin-9; Lipocortin I; Phospholipase A2 inhibitory protein; p35
Protein Family:Annexin
UniProt Gene Name:ANXA1  
UniProt Entry Name:ANXA1_HUMAN
ELISA Kits
Mouse ANXA1 (Annexin A1) ELISA Kit (MOFI01462)
Mouse Annexin A1 (Anxa1) ELISA Kit
Secondary Antibody
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)
Recommended Products
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011)
Anti-HRP-conjugated Beta Actin Antibody (CABC028)

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