ANTXR1 Rabbit Polyclonal Antibody (CAB6525)
- SKU:
- CAB6525
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
Product Name: | ANTXR1 Rabbit Polyclonal Antibody |
SKU: | CAB6525 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 84-333 of human ANTXR1 (NP_060623.2). |
Sequence: | VFST RGTT LMKL TEDR EQIR QGLE ELQK VLPG GDTY MHEG FERA SEQI YYEN RQGY RTAS VIIA LTDG ELHE DLFF YSER EANR SRDL GAIV YCVG VKDF NETQ LARI ADSK DHVF PVND GFQA LQGI IHSI LKKS CIEI LAAE PSTI CAGE SFQV VVRG NGFR HARN VDRV LCSF KIND SVTL NEKP FSVE DTYL LCPA PILK EVGM KAAL QVSM NDGL SFIS SSVI ITTT HCSL HKIA SGPT TAAC ME |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | ATR; GAPO; TEM8; ANTXR1 |
Positive Sample: | NCI-H460,HeLa,Mouse ovary,Mouse spleen |
Conjugate: | Unconjugated |
Cellular Localization: | Cell membrane, Cell projection, Single-pass type I membrane protein, filopodium membrane, lamellipodium membrane. |
Calculated MW: | 63kDa |
Observed MW: | 75kDa |
This gene encodes a type I transmembrane protein and is a tumor-specific endothelial marker that has been implicated in colorectal cancer. The encoded protein has been shown to also be a docking protein or receptor for Bacillus anthracis toxin, the causative agent of the disease, anthrax. The binding of the protective antigen (PA) component, of the tripartite anthrax toxin, to this receptor protein mediates delivery of toxin components to the cytosol of cells. Once inside the cell, the other two components of anthrax toxin, edema factor (EF) and lethal factor (LF) disrupt normal cellular processes. Three alternatively spliced variants that encode different protein isoforms have been described.
Purification Method: | Affinity purification |
Gene ID: | 84168 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |