SERPINC1 Rabbit Polyclonal Antibody (CAB1574)
- SKU:
- CAB1574
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cardiovascular
Description
Product Name: | SERPINC1 Rabbit Polyclonal Antibody |
SKU: | CAB1574 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 33-259 of human SERPINC1 (NP_000479.1). |
Sequence: | HGSP VDIC TAKP RDIP MNPM CIYR SPEK KATE DEGS EQKI PEAT NRRV WELS KANS RFAT TFYQ HLAD SKND NDNI FLSP LSIS TAFA MTKL GACN DTLQ QLME VFKF DTIS EKTS DQIH FFFA KLNC RLYR KANK SSKL VSAN RLFG DKSL TFNE TYQD ISEL VYGA KLQP LDFK ENAE QSRA AINK WVSN KTEG RITD VIPS EAIN ELTV LVLV NTIY FKGL WKS |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:100 - 1:500 |
Synonyms: | AT3; AT3D; ATIII; THPH7; ATIII-R2; ATIII-T1; ATIII-T2; SERPINC1 |
Positive Sample: | Mouse plasma,Rat plasma |
Conjugate: | Unconjugated |
Cellular Localization: | Secreted, extracellular space. |
Calculated MW: | 58kDa |
Observed MW: | 58kDa |
The protein encoded by this gene, antithrombin III, is a plasma protease inhibitor and a member of the serpin superfamily. This protein inhibits thrombin as well as other activated serine proteases of the coagulation system, and it regulates the blood coagulation cascade. The protein includes two functional domains: the heparin binding-domain at the N-terminus of the mature protein, and the reactive site domain at the C-terminus. The inhibitory activity is enhanced by the presence of heparin. Numerous mutations have been identified for this gene, many of which are known to cause antithrombin-III deficiency which constitutes a strong risk factor for thrombosis. A reduction in the serum level of this protein is associated with severe cases of Coronavirus Disease 19 (COVID-19).
Purification Method: | Affinity purification |
Gene ID: | 462 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3. |