The ZIC1 Monoclonal Antibody (CAB19558) is an essential tool for researchers studying the ZIC1 protein, a transcription factor involved in various biological processes, including embryonic development and cell differentiation. This antibody, produced through a monoclonal process, exhibits high specificity and sensitivity towards ZIC1 in human samples and is validated for use in immunohistochemistry and Western blotting applications. By targeting the ZIC1 protein, this antibody allows for precise detection and analysis in different cell types, facilitating research in developmental biology and cancer biology.
ZIC1, a member of the zinc finger protein family, plays a crucial role in the regulation of gene expression and cellular proliferation. Its involvement in embryonic patterning and tissue differentiation underscores its significance in developmental biology, making it a compelling target for investigation in developmental disorders and cancer progression. Understanding the functions of ZIC1 is key to unraveling its impact on cellular processes and potentially identifying therapeutic strategies for related diseases.
Product Name:
ZIC1 Rabbit Monoclonal Antibody
SKU:
CAB19558
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human ZIC1 (Q15915).
This gene encodes a member of the ZIC family of C2H2-type zinc finger proteins. Members of this family are important during development. Aberrant expression of this gene is seen in medulloblastoma, a childhood brain tumor. This gene is closely linked to the gene encoding zinc finger protein of the cerebellum 4, a related family member on chromosome 3. This gene encodes a transcription factor that can bind and transactivate the apolipoprotein E gene.
Purification Method:
Affinity purification
Gene ID:
7545
Clone Number:
ARC2173
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using ZIC1 Rabbit mAb (CAB19558) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
