The Anti-Y14/RBM8A Antibody (CAB19599) offered by Assay Genie is a valuable tool for researchers studying the Y14/RBM8A protein, which plays a key role in mRNA splicing and export. This polyclonal antibody, produced in rabbits, exhibits high specificity and sensitivity when detecting Y14/RBM8A in human samples, making it suitable for use in Western blot applications.Y14/RBM8A is a crucial protein involved in the splicing of pre-mRNA and the export of mature mRNA from the nucleus to the cytoplasm. Dysregulation of this process can have profound impacts on gene expression and cellular function, and is implicated in various diseases, including cancer. By targeting Y14/RBM8A with this antibody, researchers can gain insights into its expression levels, localization, and interactions with other proteins, advancing our understanding of mRNA processing mechanisms.
This antibody is an essential tool for investigations into gene expression regulation, RNA processing, and the pathogenesis of diseases associated with mRNA splicing defects. Its specificity and reliability make it an ideal choice for researchers in the fields of molecular biology, genetics, and oncology looking to unravel the complexities of mRNA metabolism and its role in health and disease. Unlock the potential of your research with the Anti-Y14/RBM8A Antibody from Assay Genie.
Product Name:
Y14/RBM8A Rabbit Monoclonal Antibody
SKU:
CAB19599
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human Y14/RBM8A (Q9Y5S9).
This gene encodes a protein with a conserved RNA-binding motif. The protein is found predominantly in the nucleus, although it is also present in the cytoplasm. It is preferentially associated with mRNAs produced by splicing, including both nuclear mRNAs and newly exported cytoplasmic mRNAs. It is thought that the protein remains associated with spliced mRNAs as a tag to indicate where introns had been present, thus coupling pre- and post-mRNA splicing events. Previously, it was thought that two genes encode this protein, RBM8A and RBM8B; it is now thought that the RBM8B locus is a pseudogene. There are two alternate translation start codons with this gene, which result in two forms of the protein. An allele mutation and a low-frequency noncoding single-nucleotide polymorphism (SNP) in this gene cause thrombocytopenia-absent radius (TAR) syndrome.
Purification Method:
Affinity purification
Gene ID:
9939
Clone Number:
ARC2189
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using Y14/RBM8A Rabbit mAb (CAB19599) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 20s.
