Y14/RBM8A Rabbit Monoclonal Antibody (CAB19599)
- SKU:
- CAB19599
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- BOV-1A
- BOV-1B
- BOV-1C
- C1DELq21.1
- DEL1q21.1
- MDS014
- RBM8
- RBM8B
- TAR
- Y14
- ZNRP
- ZRNP1
- Research Area:
- Epigenetics and Nuclear Signaling
Description
Product Name: | Y14/RBM8A Rabbit Monoclonal Antibody |
SKU: | CAB19599 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human Y14/RBM8A (Q9Y5S9). |
Sequence: | MADV LDLH EAGG EDFA MDED GDES IHKL KEKA KKRK GRGF GSEE GSRA RMRE DYDS VEQD GDEP GPQR SVEG WILF VTGV HEEA TEED IHDK FAEY GEIK |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | TAR; Y14; RBM8; ZNRP; RBM8B; ZRNP1; BOV-1A; BOV-1B; BOV-1C; MDS014; DEL1q21.1; C1DELq21.1; Y14/RBM8A |
Positive Sample: | HT-29,293T,Jurkat,Mouse lung,Mouse brain,Rat lung,Rat brain,Rat spleen |
Conjugate: | Unconjugated |
Cellular Localization: | cytoplasm, cytosol, nuclear speck, nucleoplasm, nucleus |
Calculated MW: | 20kDa |
Observed MW: | 20kDa |
This gene encodes a protein with a conserved RNA-binding motif. The protein is found predominantly in the nucleus, although it is also present in the cytoplasm. It is preferentially associated with mRNAs produced by splicing, including both nuclear mRNAs and newly exported cytoplasmic mRNAs. It is thought that the protein remains associated with spliced mRNAs as a tag to indicate where introns had been present, thus coupling pre- and post-mRNA splicing events. Previously, it was thought that two genes encode this protein, RBM8A and RBM8B; it is now thought that the RBM8B locus is a pseudogene. There are two alternate translation start codons with this gene, which result in two forms of the protein. An allele mutation and a low-frequency noncoding single-nucleotide polymorphism (SNP) in this gene cause thrombocytopenia-absent radius (TAR) syndrome.
Purification Method: | Affinity purification |
Gene ID: | 9939 |
Clone Number: | ARC2189 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3. |