The XPD/ERCC2 Polyclonal Antibody (CAB19241) is a valuable tool for research into the XPD/ERCC2 protein, which plays a key role in DNA repair mechanisms. This antibody, produced in rabbits, exhibits high reactivity with human samples and is specifically validated for use in Western blot applications. By targeting the XPD/ERCC2 protein, researchers can explore its functions in DNA repair pathways and its implications in various cellular processes.XPD/ERCC2, a member of the nucleotide excision repair complex, is essential for maintaining genomic stability and preventing mutations that can lead to diseases such as cancer.
Understanding the role of XPD/ERCC2 in DNA repair mechanisms can provide insights into potential therapeutic strategies for cancer treatment and other genetic disorders. This antibody enables the detection and analysis of XPD/ERCC2 expression in different cell types, making it a versatile tool for studies in molecular biology and oncology research.
Product Name:
XPD/ERCC2 Rabbit Monoclonal Antibody
SKU:
CAB19241
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 600-700 of human XPD/ERCC2 (P18074).
The nucleotide excision repair pathway is a mechanism to repair damage to DNA. The protein encoded by this gene is involved in transcription-coupled nucleotide excision repair and is an integral member of the basal transcription factor BTF2/TFIIH complex. The gene product has ATP-dependent DNA helicase activity and belongs to the RAD3/XPD subfamily of helicases. Defects in this gene can result in three different disorders, the cancer-prone syndrome xeroderma pigmentosum complementation group D, trichothiodystrophy, and Cockayne syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
2068
Clone Number:
ARC2401
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates using XPD/ERCC2 Rabbit mAb (CAB19241) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
