[KO Validated] XIAP Monoclonal Antibody (CAB20846)
- SKU:
- CAB20846
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
Description
Product Name: | [KO Validated] XIAP Monoclonal Antibody |
SKU: | CAB20846 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human XIAP (NP_001158.2). |
Sequence: | MTFN SFEG SKTC VPAD INKE EEFV EEFN RLKT FANF PSGS PVSA STLA RAGF LYTG EGDT VRCF SCHA AVDR WQYG DSAV GRHR KVSP NCRF INGF YLEN SATQ STNS GIQN GQYK VENY LGSR DHFA LDRP SETH ADYL LRTG QVVD ISDT IYPR NPAM YSEE ARLK SFQN WPDY AHLT PREL ASAG LYYT GIGD QVQC |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:2000 - 1:6000 |
Synonyms: | API3; ILP1; MIHA; XLP2; BIRC4; IAP-3; hIAP3; hIAP-3; AP |
Positive Sample: | HeLa,RAW 264.7,PC-12 |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm, Nucleus. |
Calculated MW: | 57kDa |
Observed MW: | 53kDa |
This gene encodes a protein that belongs to a family of apoptotic suppressor proteins. Members of this family share a conserved motif termed, baculovirus IAP repeat, which is necessary for their anti-apoptotic function. This protein functions through binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2 and inhibits apoptosis induced by menadione, a potent inducer of free radicals, and interleukin 1-beta converting enzyme. This protein also inhibits at least two members of the caspase family of cell-death proteases, caspase-3 and caspase-7. Mutations in this gene are the cause of X-linked lymphoproliferative syndrome. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 2 and 11.
Purification Method: | Affinity purification |
Gene ID: | 331 |
Clone Number: | ARC51953 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3. |