The XCR1 Polyclonal Antibody (CAB20258) is a valuable tool for researchers studying XCR1, a chemokine receptor known for its role in dendritic cell function and immune response regulation. This antibody, produced in rabbits, exhibits high reactivity towards human samples and has been validated for use in Western blot applications.XCR1 is known to be involved in the migration and activation of dendritic cells, which play a crucial role in initiating and regulating immune responses. By specifically binding to the XCR1 protein, this antibody enables precise detection and analysis in various cell types, making it an essential resource for studies in immunology, vaccine development, and infectious disease research.
The unique properties of XCR1 make it a promising target for investigating immune cell dynamics and exploring potential therapeutic interventions for conditions such as cancer, infectious diseases, and autoimmune disorders. By elucidating the mechanisms by which XCR1 influences immune function, researchers can gain valuable insights into disease pathogenesis and develop novel strategies for immune modulation and intervention.
Product Name:
XCR1 Rabbit Polyclonal Antibody
SKU:
CAB20258
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human XCR1 (NP_001019815.1).
The protein encoded by this gene is a chemokine receptor belonging to the G protein-coupled receptor superfamily. The family members are characterized by the presence of 7 transmembrane domains. The encoded protein transduces a signal by increasing the intracellular calcium ion level. The viral macrophage inflammatory protein-II is an antagonist of this receptor and blocks signaling. Some studies have implicated a cluster of genes at 3p21.31, including this gene, as associated with COVID-19 risk. The encoded protein may also play a role in cell proliferation and migration in several types of cancer.
Purification Method:
Affinity purification
Gene ID:
2829
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Immunohistochemistry analysis of paraffin-embedded rat thymus using XCR1 Rabbit pAb (CAB20258) at dilution of 1:100 (40x lens).Perform microwave antigen retrieval with 10 mM Tris/EDTA buffer pH 9.0 before commencing with IHC staining protocol.
