VDR Monoclonal Antibody (CAB20840)
- SKU:
- CAB20840
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
Description
Product Name: | VDR Monoclonal Antibody |
SKU: | CAB20840 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human VDR (NP_000367.1). |
Sequence: | MEAM AAST SLPD PGDF DRNV PRIC GVCG DRAT GFHF NAMT CEGC KGFF RRSM KRKA LFTC PFNG DCRI TKDN RRHC QACR LKRC VDIG MMKE FILT DEEV QRKR EMIL KRKE EEAL KDSL RPKL SEEQ QRII AILL DAHH KTYD PTYS DFCQ FRPP VRVN DGGG SHPS RPNS RHTP SFSG DSSS SCSD HCIT SSDM MDSS SFSN LDLS EEDS DDPS VTLE LSQL SMLP HLAD LVSY SIQK VIGF AKMI PGFR DLTS EDQI VLLK SSAI EVIM LRSN ESFT MDDM SWTC GNQD YKYR VSDV |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 |
Synonyms: | NR1I1; PPP1R163; VDR |
Positive Sample: | HeLa,Mouse kidney |
Conjugate: | Unconjugated |
Cellular Localization: | Nucleus. |
Calculated MW: | 48kDa |
Observed MW: | 48kDa |
This gene encodes vitamin D3 receptor, which is a member of the nuclear hormone receptor superfamily of ligand-inducible transcription factors. This receptor also functions as a receptor for the secondary bile acid, lithocholic acid. Downstream targets of vitamin D3 receptor are principally involved in mineral metabolism, though this receptor regulates a variety of other metabolic pathways, such as those involved in immune response and cancer. Mutations in this gene are associated with type II vitamin D-resistant rickets. A single nucleotide polymorphism in the initiation codon results in an alternate translation start site three codons downstream. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. A recent study provided evidence for translational readthrough in this gene, and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon.
Purification Method: | Affinity purification |
Gene ID: | 7421 |
Clone Number: | ARC51248 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3. |