The VAV3 Polyclonal Antibody (CAB9583) is a valuable tool for researchers studying VAV3, a protein involved in cell signaling pathways related to cell proliferation, migration, and differentiation. This antibody, produced in rabbits, exhibits high specificity towards human samples and has been validated for use in Western blot and immunofluorescence applications.VAV3 is a guanine nucleotide exchange factor that plays a crucial role in regulating cytoskeletal dynamics and cell adhesion, making it a key player in processes such as cell migration and invasion. Dysregulation of VAV3 has been implicated in various diseases, including cancer, where it promotes tumor growth and metastasis.
By targeting VAV3 with the CAB9583 antibody, researchers can gain insights into the protein's function and its impact on cellular processes. This antibody enables the detection and analysis of VAV3 in different cell types, making it a valuable tool for studies in cancer biology and cell signaling pathways. Understanding the role of VAV3 in disease pathogenesis may lead to the development of targeted therapies for cancer and other related disorders.
Product Name:
VAV3 Rabbit Monoclonal Antibody
SKU:
CAB9583
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 700-800 of human VAV3 (Q9UKW4).
This gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. This gene product acts as a GEF preferentially for RhoG, RhoA, and to a lesser extent, RAC1, and it associates maximally with the nucleotide-free states of these GTPases. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
Purification Method:
Affinity purification
Gene ID:
10451
Clone Number:
ARC1647
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates using VAV3 Rabbit mAb (CAB9583) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 180s.
