The USP11 Polyclonal Antibody (CAB20179) is a valuable tool for researchers studying USP11, a deubiquitinating enzyme involved in key cellular processes such as DNA repair and cell cycle regulation. This antibody, produced in rabbits, exhibits high specificity for human samples and has been rigorously validated for use in Western blot applications. By binding to the USP11 protein, researchers can accurately detect and analyze its expression in a variety of cell types, making it an essential component for studies in molecular biology and cancer research.
USP11, also known as ubiquitin-specific protease 11, plays a critical role in maintaining genomic stability and cell viability by governing the turnover of key proteins involved in these processes. Its association with DNA damage response pathways and cell cycle checkpoints underscores its importance in safeguarding against genetic abnormalities and tumor development. By elucidating the mechanisms through which USP11 operates, scientists can gain valuable insights into potential therapeutic targets for cancer and other proliferative disorders.
Product Name:
USP11 Rabbit Polyclonal Antibody
SKU:
CAB20179
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 70-190 of human USP11 (NP_004642.2).
Protein ubiquitination controls many intracellular processes, including cell cycle progression, transcriptional activation, and signal transduction. This dynamic process, involving ubiquitin conjugating enzymes and deubiquitinating enzymes, adds and removes ubiquitin. Deubiquitinating enzymes are cysteine proteases that specifically cleave ubiquitin from ubiquitin-conjugated protein substrates. This gene encodes a deubiquitinating enzyme which lies in a gene cluster on chromosome Xp11.23
Purification Method:
Affinity purification
Gene ID:
8237
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using USP11 Rabbit pAb (CAB20179) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
