The Anti-UPP1 Antibody (CAB0613) is a valuable tool for research involving the UPP1 protein, which plays a key role in the uridine phosphorylase pathway that regulates DNA and RNA metabolism. This polyclonal antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications.UPP1 is a critical enzyme involved in the salvage pathway for nucleotide synthesis, making it essential for cellular proliferation and growth. Its dysregulation has been linked to various diseases, including cancer and metabolic disorders. By targeting UPP1 with this antibody, researchers can study its expression levels and activity in different cell types, providing valuable insights into its function and potential therapeutic applications.
With its ability to specifically bind to UPP1, this antibody enables accurate detection and analysis of the protein in experimental settings, making it an ideal choice for studies in molecular biology, biochemistry, and pharmaceutical research. By understanding the role of UPP1 in cellular metabolism and disease development, researchers can uncover new avenues for targeted therapies and drug discovery.
Product Name:
UPP1 Rabbit Monoclonal Antibody
SKU:
CAB0613
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Not found
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human UPP1 (Q16831).
Sequence:
MAAT GANA EKAE SHND CPVR LLNP NIAK MKED ILYH FNLT TSRH NFPA LFGD VKFV CVGG SPSR MKAF IRCV GAEL GLDC PGRD YPNI CAGT DRYA MYKV
Tested Applications:
WBELISA
Recommended Dilution:
WB,1:500 - 1:1000
Synonyms:
UP; UPP; UPASE; UDRPASE; UPP1
Positive Sample:
HeLa,293T,Rat large intestine,Rat lung,Rat heart,Mouse large intestine,Mouse lung,Mouse kidney
Conjugate:
Unconjugated
Cellular Localization:
Cytosol, Nucleoplasm
Calculated MW:
34kDa
Observed MW:
34kDa
This gene encodes a uridine phosphorylase, an enzyme that catalyzes the reversible phosphorylation of uridine (or 2'- deoxyuridine) to uracil and ribose-1-phosphate (or deoxyribose-1-phosphate). The encoded enzyme functions in the degradation and salvage of pyrimidine ribonucleosides.
Purification Method:
Affinity purification
Gene ID:
7378
Clone Number:
ARC2531
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using UPP1 antibody (CAB0613) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 3s.
