The Anti-UPA Chimeric Recombinant Rabbit Monoclonal Antibody (HDAB0278) is a cutting-edge tool for researchers studying the urokinase plasminogen activator (UPA) protein. UPA is a crucial enzyme involved in the breakdown of extracellular matrix and has been implicated in various biological processes, including cancer metastasis, inflammation, and tissue remodeling.This antibody, developed using advanced technology and recombinant DNA techniques, specifically targets the UPA protein with high affinity and specificity. It is suitable for use in a variety of applications, including Western blotting, immunofluorescence, and immunohistochemistry, allowing for the detection and localization of UPA in different experimental settings.
By utilizing the Anti-UPA Chimeric Recombinant Rabbit Monoclonal Antibody, researchers can gain valuable insights into the role of UPA in disease processes and potentially identify novel targets for therapeutic intervention. Its superior performance and reliability make it an essential tool for studies in cancer biology, inflammation research, and other fields where UPA is a key player.
SKU:
HDAB0278
Size:
100 µg
Clonality:
Monoclonal
Clone:
DMC440
Synonyms:
ATF, BDPLT5, QPD, u-PA, UPA, URK
Applications:
Flow Cyt
Recommended Dilution:
Flow Cyt 1:100
Host Species:
Rabbit
Isotype:
Rabbit/Human Fc chimeric IgG1
Reactivity:
Human
Purification Method:
Purified from cell culture supernatant by affinity chromatography
Formulation:
Powder
Buffer:
1XPBS
Storage:
Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing).Lyophilized antibodies are shipped at ambient temperature.
Usage:
Research use only
Background:
This gene encodes a secreted serine protease that converts plasminogen to plasmin. The encoded preproprotein is proteolytically processed to generate A and B polypeptide chains. These chains associate via a single disulfide bond to form the catalytically inactive high molecular weight urokinase-type plasminogen activator (HMW-uPA). HMW-uPA can be further processed into the catalytically active low molecular weight urokinase-type plasminogen activator (LMW-uPA). This low molecular weight form does not bind to the urokinase-type plasminogen activator receptor. Mutations in this gene may be associated with Quebec platelet disorder and late-onset Alzheimer's disease. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed.
