The Anti-UBE4B Antibody (CAB0419) is a high-quality antibody specifically designed for research involving UBE4B, a key protein involved in protein degradation and cellular regulation processes. This polyclonal antibody, generated in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. UBE4B, also known as U-box domain-containing protein 4B, plays a crucial role in targeting proteins for degradation through the ubiquitin-proteasome pathway. Dysregulation of UBE4B has been implicated in various diseases, including cancer and neurodegenerative disorders.
Therefore, studying the function and regulation of UBE4B is essential for gaining insights into these pathological conditions.This antibody allows for precise detection and analysis of UBE4B in various cell types, making it a valuable tool for researchers in the fields of cell biology, molecular biology, and oncology. By understanding the role of UBE4B in disease progression, potential therapeutic targets and strategies can be identified for the development of innovative treatments.
Product Name:
UBE4B Rabbit Monoclonal Antibody
SKU:
CAB0419
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human UBE4B (O95155).
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes an additional conjugation factor, E4, which is involved in multiubiquitin chain assembly. This gene is also the strongest candidate in the neuroblastoma tumor suppressor genes. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
10277
Clone Number:
ARC2503
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using UBE4B antibody (CAB0419) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
