The TSLP Chimeric Recombinant Rabbit Monoclonal Antibody (HDAB0270) offered by Assay Genie is a cutting-edge tool for researchers working in the field of immunology. This antibody specifically targets Thymic Stromal Lymphopoietin (TSLP), a cytokine that plays a crucial role in the initiation and modulation of immune responses, particularly in allergic inflammation.Raised in rabbits, this highly reactive antibody is validated for use in a variety of applications, including Western blotting, enabling researchers to detect and analyze TSLP in human samples with precision and reliability. By targeting TSLP, researchers can gain valuable insights into the mechanisms underlying immune responses and inflammation, paving the way for the development of new therapies for conditions such as allergies, asthma, and atopic dermatitis.
With its ability to detect and study TSLP in various cell types, the TSLP Chimeric Recombinant Rabbit Monoclonal Antibody (HDAB0270) is a valuable tool for advancing research in immunology and related fields. Its high specificity and sensitivity make it an essential component of any researcher's toolkit for investigating the complex interplay between immune responses and allergic reactions.
SKU:
HDAB0270
Size:
100 µg
Clonality:
Monoclonal
Clone:
DMC426
Synonyms:
TSLP
Applications:
Flow Cyt
Recommended Dilution:
Flow Cyt 1:100
Host Species:
Rabbit
Isotype:
Rabbit/Human Fc chimeric IgG1
Reactivity:
Human
Purification Method:
Purified from cell culture supernatant by affinity chromatography
Formulation:
Powder
Buffer:
1XPBS
Storage:
Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing).Lyophilized antibodies are shipped at ambient temperature.
Usage:
Research use only
Background:
This gene encodes a hemopoietic cytokine proposed to signal through a heterodimeric receptor complex composed of the thymic stromal lymphopoietin receptor and the IL-7R alpha chain. It mainly impacts myeloid cells and induces the release of T cell-attracting chemokines from monocytes and enhances the maturation of CD11c( ) dendritic cells. The protein promotes T helper type 2 (TH2) cell responses that are associated with immunity in various inflammatory diseases, including asthma, allergic inflammation and chronic obstructive pulmonary disease. The protein is therefore considered a potential therapeutic target for the treatment of such diseases. In addition, the shorter (predominant) isoform is an antimicrobial protein, displaying antibacterial and antifungal activity against B. cereus, E. coli, E. faecalis, S. mitis, S. epidermidis, and C. albicans. Alternative splicing of this gene results in multiple transcript variants.
