The TSC2 Polyclonal Antibody (CAB0491) is a valuable tool for research involving TSC2, a tumor suppressor protein implicated in the development of tuberous sclerosis complex (TSC), a genetic disorder characterized by the growth of benign tumors in various organs. The antibody, produced in rabbits, is highly specific for human TSC2 and has been validated for use in Western blot applications. It binds specifically to the TSC2 protein, allowing for the detection and analysis of TSC2 expression in different cell types.TSC2 plays a crucial role in the regulation of cell growth and proliferation by inhibiting the activity of the mTOR pathway.
Dysregulation of TSC2 function is associated with the development of TSC and other related conditions, making it a key target for research in cancer biology and developmental disorders. Understanding the role of TSC2 in cellular processes is essential for developing targeted therapies for TSC and other diseases driven by mTOR pathway dysregulation. Overall, the TSC2 Polyclonal Antibody is a valuable tool for researchers studying TSC2 function and its implications in disease pathogenesis, providing insights that can lead to the development of novel therapeutic strategies for TSC and related conditions.
Product Name:
TSC2 Rabbit Polyclonal Antibody
SKU:
CAB0491
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1160-1255 of human TSC2 (NP_000539.2).
This gene is a tumor suppressor gene that encodes the growth inhibitory protein tuberin. Tuberin interacts with hamartin to form the TSC protein complex which functions in the control of cell growth. This TSC protein complex negatively regulates mammalian target of rapamycin complex 1 (mTORC1) signaling which is a major regulator of anabolic cell growth. Mutations in this gene have been associated with tuberous sclerosis and lymphangioleiomyomatosis.
Purification Method:
Affinity purification
Gene ID:
7249
Storage Buffer:
Store at -20℃ Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of various lysates using TSC2 Rabbit pAb (CAB0491) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
