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TSC2 Rabbit Polyclonal Antibody (CAB0491)

SKU:
CAB0491
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
LAM
PPP1R160
TSC4
TSC2
Research Area:
Immunology
€139 - €419
Frequently bought together:

Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:TSC2 Rabbit Polyclonal Antibody
SKU:CAB0491
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human,Mouse,Rat
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1160-1255 of human TSC2 (NP_000539.2).
Sequence:TAPA AKPE KASA GTRV PVQE KTNL AAYV PLLT QGWA EILV RRPT GNTS WLMS LENP LSPF SSDI NNMP LQEL SNAL MAAE RFKE HRDT ALYK SLSV
Tested Applications:WB IHC-P ELISA
Recommended Dilution:WB,1:500 - 1:1000 IHC-P,1:50 - 1:200
Synonyms:LAM; TSC4; PPP1R160; TSC2
Positive Sample:293T,Mouse brain
Conjugate:Unconjugated
Cellular Localization:Cytoplasm, Membrane, Peripheral membrane protein.
Calculated MW:201kDa
Observed MW:200kDa

This gene is a tumor suppressor gene that encodes the growth inhibitory protein tuberin. Tuberin interacts with hamartin to form the TSC protein complex which functions in the control of cell growth. This TSC protein complex negatively regulates mammalian target of rapamycin complex 1 (mTORC1) signaling which is a major regulator of anabolic cell growth. Mutations in this gene have been associated with tuberous sclerosis and lymphangioleiomyomatosis.

Purification Method:Affinity purification
Gene ID:7249
Storage Buffer:Store at -20℃ Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Product ImageWestern blot analysis of various lysates using TSC2 Rabbit pAb (CAB0491) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.

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