The Anti-TrkA/B/C Antibody (CAB2693) is a valuable tool for researchers studying the TrkA/B/C receptor family, which plays a crucial role in neurotrophic signaling. This antibody is produced in rabbit and is highly specific for human samples, making it ideal for Western blot applications. By binding to the TrkA/B/C proteins, researchers can effectively detect and analyze these receptors in various cell types.The TrkA/B/C receptors are known for their involvement in neuronal development, function, and survival. Aberrant signaling through these receptors has been linked to neurological disorders, such as Alzheimer's disease and neuroblastoma.
Additionally, studies have shown that Trk receptors are also implicated in cancer progression, making them attractive targets for therapeutic intervention.By using the Anti-TrkA/B/C Antibody (CAB2693), researchers can better understand the role of these receptors in health and disease. This antibody is a valuable tool for investigating neurotrophic signaling pathways, as well as for exploring potential targeted therapies for neurological disorders and cancer.
Product Name:
TrkA+B+C Rabbit Monoclonal Antibody
SKU:
CAB2693
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 722-822 of human NTRK2 (Q16620 ).
Axon, dendrite, early endosome, late endosome, plasma membrane
Calculated MW:
140kDa
This gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, cognitive disability and cancer. Alternate transcriptional splice variants of this gene have been found, but only three have been characterized to date.This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation and may play a role in the development of proprioceptive neurons that sense body position. Mutations in this gene have been associated with medulloblastomas, secretory breast carcinomas and other cancers. Several transcript variants encoding different isoforms have been found for this gene. This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation. Mutations in this gene have been associated with obesity and mood disorders. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
4914/4916/4915
Clone Number:
ARC2649
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates using TrkA+B+C Rabbit mAb (CAB2693) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
