The TRIM24 Polyclonal Antibody (CAB20938) is a valuable tool for researchers studying TRIM24, a protein involved in various cellular processes, including gene regulation and tumorigenesis. This antibody, produced in rabbits, is highly specific for human samples and has been validated for use in Western blot applications. By binding to TRIM24, this antibody enables the detection and analysis of the protein in a variety of cell types, making it ideal for studies in cancer research and molecular biology.
TRIM24, also known as TIF1α, is a transcriptional co-regulator that plays a crucial role in gene expression and cellular proliferation. Dysregulation of TRIM24 has been linked to the development and progression of various cancers, making it a promising target for cancer therapy research. By understanding the function of TRIM24, researchers can uncover new insights into the molecular mechanisms underlying cancer and potentially develop targeted treatments to combat this disease.
Product Name:
TRIM24 Monoclonal Antibody
SKU:
CAB20938
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 400-500 of human TRIM24 (O15164).
Sequence:
TNNT IQFH CDPS FWAQ NIIN LGSL VIED KESQ PQMP KQNP VVEQ NSQP PSGL SSNQ LSKF PTQI SLAQ LRLQ HMQQ QVMA QRQQ VQRR PAPV GLPN PRMQ G
The protein encoded by this gene mediates transcriptional control by interaction with the activation function 2 (AF2) region of several nuclear receptors, including the estrogen, retinoic acid, and vitamin D3 receptors. The protein localizes to nuclear bodies and is thought to associate with chromatin and heterochromatin-associated factors. The protein is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains - a RING, a B-box type 1 and a B-box type 2 - and a coiled-coil region. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene.
Purification Method:
Affinity purification
Gene ID:
8805
Clone Number:
ARC2920
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using TRIM24 antibody (CAB20938) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
