TPMT Monoclonal Antibody (CAB20922)
- SKU:
- CAB20922
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Plant
- Host Species:
- Rabbit
- Isotype:
- IgG
Frequently bought together:
Description
Product Name: | TPMT Monoclonal Antibody |
SKU: | CAB20922 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 50-150 of human TPMT (P51580). |
Sequence: | KKHL DTFL KGKS GLRV FFPL CGKA VEMK WFAD RGHS VVGV EISE LGIQ EFFT EQNL SYSE EPIT EIPG TKVF KSSS GNIS LYCC SIFD LPRT NIGK FDMI W |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 |
Synonyms: | TPMTD; TPMT |
Positive Sample: | HeLa, 293T, Hep G2, K-562, Mouse liver, Mouse brain, Mouse kidney, Rat liver, Rat kidney |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm. |
Calculated MW: | 28kDa |
Observed MW: | 28-32kDa |
This gene encodes the enzyme that metabolizes thiopurine drugs via S-adenosyl-L-methionine as the S-methyl donor and S-adenosyl-L-homocysteine as a byproduct. Thiopurine drugs such as 6-mercaptopurine are used as chemotherapeutic agents. Genetic polymorphisms that affect this enzymatic activity are correlated with variations in sensitivity and toxicity to such drugs within individuals, causing thiopurine S-methyltransferase deficiency. Related pseudogenes have been identified on chromosomes 3, 18 and X.
Purification Method: | Affinity purification |
Gene ID: | 7172 |
Clone Number: | ARC2897 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3. |