The Anti-Torsina (TOR1A) Antibody (CAB9579) is a valuable tool for researchers studying Torsina, a AAA+ ATPase protein involved in various cellular functions, including protein folding and transport. This polyclonal antibody, produced in rabbits, is highly specific and reactive with human samples, making it an excellent choice for Western blot and immunofluorescence applications.Torsina is a key player in the pathogenesis of DYT1 dystonia, a movement disorder characterized by involuntary muscle contractions. By targeting Torsina with this antibody, researchers can gain insights into the molecular mechanisms underlying DYT1 dystonia and potentially identify new therapeutic targets for the treatment of this debilitating condition.
In addition to its relevance in neurological disorders, Torsina has also been linked to other cellular processes, such as protein quality control and vesicle trafficking. The Anti-Torsina (TOR1A) Antibody (CAB9579) provides a powerful tool for elucidating the role of Torsina in these processes and advancing our understanding of its physiological functions.
Product Name:
Torsin A Rabbit Monoclonal Antibody
SKU:
CAB9579
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 233-332 of human TorsinA/TOR1A (O14656).
The protein encoded by this gene is a member of the AAA family of adenosine triphosphatases (ATPases), is related to the Clp protease/heat shock family and is expressed prominently in the substantia nigra pars compacta. Mutations in this gene result in the autosomal dominant disorder, torsion dystonia 1.
Purification Method:
Affinity purification
Gene ID:
1861
Clone Number:
ARC1645
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using TorsinA/TOR1A antibody (CAB9579) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
