The TNFSF15 Chimeric Recombinant Rabbit Monoclonal Antibody (HDAB0290) is a powerful tool for research involving TNFSF15, a key cytokine involved in immune regulation and inflammation. This antibody, developed using cutting-edge technology, offers high specificity and sensitivity for detecting TNFSF15 in various samples.TNFSF15, also known as TL1A, is known to play a crucial role in the regulation of immune responses, particularly in autoimmune diseases and inflammatory conditions. By targeting TNFSF15, researchers can gain insights into the underlying mechanisms of these diseases and potentially develop targeted therapies to modulate immune responses.
The TNFSF15 Chimeric Recombinant Rabbit Monoclonal Antibody is validated for use in multiple applications, including Western blotting and immunohistochemistry, providing researchers with a versatile tool for studying TNFSF15 expression and activity in different experimental settings. Its high specificity and sensitivity make it an ideal choice for studies in immunology, cancer research, and other related fields.
SKU:
HDAB0290
Size:
100 µg
Clonality:
Monoclonal
Clone:
DMC464
Synonyms:
TL1, VEGI
Applications:
Flow Cyt
Recommended Dilution:
Flow Cyt 1:100
Host Species:
Rabbit
Isotype:
Rabbit/Human Fc chimeric IgG1
Reactivity:
Human
Purification Method:
Purified from cell culture supernatant by affinity chromatography
Formulation:
Powder
Buffer:
1XPBS
Storage:
Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing).Lyophilized antibodies are shipped at ambient temperature.
Usage:
Research use only
Background:
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is abundantly expressed in endothelial cells, but is not expressed in either B or T cells. The expression of this protein is inducible by TNF and IL-1 alpha. This cytokine is a ligand for receptor TNFRSF25 and decoy receptor TNFRSF21/DR6. It can activate NF-kappaB and MAP kinases, and acts as an autocrine factor to induce apoptosis in endothelial cells. This cytokine is also found to inhibit endothelial cell proliferation, and thus may function as an angiogenesis inhibitor. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]
