The anti-TMEM106B Polyclonal Antibody (CAB20165) is a valuable tool for researchers studying TMEM106B, a transmembrane protein involved in cellular processes related to neurodegenerative diseases such as frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS). This antibody, produced in rabbits, demonstrates high reactivity with human samples and has been validated for use in Western blot applications.TMEM106B is known to play a role in lysosomal function and has been implicated in the pathogenesis of neurodegenerative disorders.
By specifically binding to the TMEM106B protein, this antibody enables precise detection and analysis in various cell types, making it an essential tool for investigations into the molecular mechanisms underlying these diseases.The in-depth study of TMEM106B using this antibody could provide crucial insights into potential therapeutic targets for neurodegenerative conditions, paving the way for the development of novel treatment strategies aimed at mitigating the progression of these debilitating disorders.
Product Name:
TMEM106B Rabbit Polyclonal Antibody
SKU:
CAB20165
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 148-274 of human TMEM106B (NP_060844.2).
Enables ATPase binding activity. Involved in dendrite morphogenesis and lysosome localization. Located in endosome and lysosomal membrane. Implicated in hypomyelinating leukodystrophy.
Purification Method:
Affinity purification
Gene ID:
54664
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using TMEM106B Rabbit pAb (CAB20165) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 5s.
