TIRAP Rabbit Monoclonal Antibody (CAB9663)
- SKU:
- CAB9663
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- BACTS1
- Mal
- MyD88-2
- wyatt
- Research Area:
- Immunology
Frequently bought together:
Description
Product Name: | TIRAP Rabbit Monoclonal Antibody |
SKU: | CAB9663 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human TIRAP (P58753). |
Sequence: | MASS TSLP APGS RPKK PLGK MADW FRQT LLKK PKKR PNSP ESTS SDAS QPTS QDSP LPPS LSSV TSPS LPPT HASD SGSS RWSK DYDV CVCH SEED LVAA |
Tested Applications: | WB IHC-P ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 IHC-P,1:50 - 1:200 |
Synonyms: | Mal; wyatt; BACTS1; MyD88-2; TIRAP |
Positive Sample: | 293T,Hep G2,THP-1,Mouse brain,Rat spleen,Rat thymus |
Conjugate: | Unconjugated |
Cellular Localization: | Cell membrane, Cytoplasm, Membrane. |
Calculated MW: | 24kDa |
Observed MW: | 32kDa |
The innate immune system recognizes microbial pathogens through Toll-like receptors (TLRs), which identify pathogen-associated molecular patterns. Different TLRs recognize different pathogen-associated molecular patterns and all TLRs have a Toll-interleukin 1 receptor (TIR) domain, which is responsible for signal transduction. The protein encoded by this gene is a TIR adaptor protein involved in the TLR4 signaling pathway of the immune system. It activates NF-kappa-B, MAPK1, MAPK3 and JNK, which then results in cytokine secretion and the inflammatory response. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described.
Purification Method: | Affinity purification |
Gene ID: | 114609 |
Clone Number: | ARC1686 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3. |