The Anti-TIRAP Antibody (CAB9663) is a highly specific and sensitive tool for studying Toll/interleukin-1 receptor (TIR) domain-containing adapter protein (TIRAP). TIRAP is a key adaptor protein involved in Toll-like receptor (TLR) signaling pathways, which play a crucial role in the innate immune response.This polyclonal antibody, generated in rabbits, is designed for use in various research applications, including Western blotting, immunofluorescence, and immunohistochemistry. It specifically targets TIRAP, allowing for the detection and analysis of TIRAP protein levels and localization in different cell types and tissues.
The Anti-TIRAP Antibody is an essential tool for researchers studying the molecular mechanisms of TLR signaling and its implications in immune responses, inflammation, and host defense against pathogens. By elucidating the role of TIRAP in these processes, this antibody can contribute to the development of novel therapeutic strategies for infectious diseases, autoimmune disorders, and inflammatory conditions.
Product Name:
TIRAP Rabbit Monoclonal Antibody
SKU:
CAB9663
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human TIRAP (P58753).
The innate immune system recognizes microbial pathogens through Toll-like receptors (TLRs), which identify pathogen-associated molecular patterns. Different TLRs recognize different pathogen-associated molecular patterns and all TLRs have a Toll-interleukin 1 receptor (TIR) domain, which is responsible for signal transduction. The protein encoded by this gene is a TIR adaptor protein involved in the TLR4 signaling pathway of the immune system. It activates NF-kappa-B, MAPK1, MAPK3 and JNK, which then results in cytokine secretion and the inflammatory response. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described.
Purification Method:
Affinity purification
Gene ID:
114609
Clone Number:
ARC1686
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates using TIRAP Rabbit mAb (CAB9663) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
