The Anti-TIN2/TINF2 Antibody (CAB9750) is a powerful tool for studying the TIN2/TINF2 protein, which plays a crucial role in telomere maintenance and regulation. This polyclonal antibody is raised in rabbits and specifically targets the TIN2/TINF2 protein in human samples, making it ideal for use in various research applications, including Western blotting.Telomeres are essential for protecting the ends of chromosomes and maintaining genomic stability. Dysregulation of telomere length and maintenance is linked to various diseases, including cancer, aging, and genetic disorders.
The TIN2/TINF2 protein is a key player in telomere protection and interaction with other telomere-associated proteins, making it an important target for further investigation.By using the Anti-TIN2/TINF2 Antibody (CAB9750), researchers can study the function and localization of TIN2/TINF2 in different cell types and conditions, providing valuable insights into telomere biology and potential therapeutic targets for telomere-related diseases. This antibody is a valuable tool for advancing research in the fields of molecular biology, genetics, and aging-related studies.
Product Name:
TIN2/TINF2 Rabbit Monoclonal Antibody
SKU:
CAB9750
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 210-309 of human TIN2/TINF2 (Q9BSI4).
Hep G2,A549,Mouse testis,Mouse thymus,Rat lung,Rat testis
Conjugate:
Unconjugated
Cellular Localization:
Chromosome, Nucleus, Nucleus matrix, telomere.
Calculated MW:
50kDa
Observed MW:
45kDa
This gene encodes one of the proteins of the shelterin, or telosome, complex which protects telomeres by allowing the cell to distinguish between telomeres and regions of DNA damage. The protein encoded by this gene is a critical part of shelterin; it interacts with the three DNA-binding proteins of the shelterin complex, and it is important for assembly of the complex. Mutations in this gene cause dyskeratosis congenita (DKC), an inherited bone marrow failure syndrome.
Purification Method:
Affinity purification
Gene ID:
26277
Clone Number:
ARC1732
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using TIN2/TINF2 Rabbit mAb (CAB9750) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
