The Anti-TIMP2 Antibody (CAB20766) is a valuable tool for researchers studying tissue inhibitor of metalloproteinase 2 (TIMP2), a crucial regulator of extracellular matrix remodeling and tissue homeostasis. This polyclonal antibody, produced in rabbits, is highly specific and reactive with human samples, making it suitable for a variety of applications including Western blot and immunohistochemistry.TIMP2 is known for its role in inhibiting matrix metalloproteinases (MMPs), enzymes involved in tissue degradation and remodeling. Dysregulation of TIMP2 has been implicated in various pathological conditions such as cancer metastasis, fibrosis, and cardiovascular diseases.
The Anti-TIMP2 Antibody enables researchers to detect and analyze TIMP2 expression levels in different cell types and tissues, providing insights into its functions and potential therapeutic targets.With its high specificity and sensitivity, the Anti-TIMP2 Antibody is an essential tool for studies in the fields of cancer biology, tissue remodeling, and cardiovascular research. By understanding the role of TIMP2 in disease processes, researchers can potentially develop targeted therapies for conditions associated with dysregulated extracellular matrix dynamics.
This gene is a member of the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. In addition to an inhibitory role against metalloproteinases, the encoded protein has a unique role among TIMP family members in its ability to directly suppress the proliferation of endothelial cells. As a result, the encoded protein may be critical to the maintenance of tissue homeostasis by suppressing the proliferation of quiescent tissues in response to angiogenic factors, and by inhibiting protease activity in tissues undergoing remodelling of the extracellular matrix.
Purification Method:
Affinity purification
Gene ID:
7077
Clone Number:
ARC51187
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using TIMP2 antibody (CAB20766) at1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 20s.
