The TIMM50 Polyclonal Antibody (CAB1536) is developed for research involving TIMM50, a protein located in the inner mitochondrial membrane that plays a critical role in mitochondrial protein import. This antibody, generated in rabbits, demonstrates strong reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to the TIMM50 protein, researchers can accurately detect and analyze its expression in various cell types, making it an excellent tool for studies in mitochondrial biology and disease research.
TIMM50 is essential for the translocation of precursor proteins into the mitochondria, ensuring proper functioning of the organelle and overall cellular health. Dysregulation of TIMM50 has been linked to mitochondrial dysfunction and a variety of diseases, including neurodegenerative disorders and metabolic conditions. Investigating the mechanisms of TIMM50 can provide valuable insights into mitochondrial biology and potential therapeutic targets for mitochondrial-related diseases.
Product Name:
TIMM50 Rabbit Monoclonal Antibody
SKU:
CAB1536
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human TIMM50 (Q3ZCQ8).
This gene encodes a subunit of the TIM23 inner mitochondrial membrane translocase complex. The encoded protein functions as the receptor subunit that recognizes the mitochondrial targeting signal, or presequence, on protein cargo that is destined for the mitochondrial inner membrane and matrix. This protein may also play a role in maintaining the membrane permeability barrier, and knockdown of this gene in human cells results in the release of cytochrome c and apoptosis.
Purification Method:
Affinity purification
Gene ID:
92609
Clone Number:
ARC1883
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates using TIMM50 Rabbit mAb (CAB1536) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
