The Anti-TGFBR2 Chimeric Recombinant Rabbit Monoclonal Antibody (HDAB0293) is a cutting-edge tool for researchers studying the TGFBR2 protein, a key player in cellular signaling pathways. This antibody, developed using advanced technology, is highly specific and sensitive for detecting TGFBR2 in various sample types, making it essential for studies in molecular biology and cancer research.TGFBR2, a receptor for the transforming growth factor beta (TGF-β) protein, plays a crucial role in regulating cell growth, differentiation, and immune response. Dysregulation of TGFBR2 signaling is implicated in various diseases, including cancer, fibrosis, and immune disorders.
Targeting TGFBR2 with specific antibodies like HDAB0293 provides valuable insights into its function and potential as a therapeutic target for these diseases.Researchers can trust the Anti-TGFBR2 Chimeric Recombinant Rabbit Monoclonal Antibody (HDAB0293) for accurate and reliable results in immunohistochemistry, immunofluorescence, and other experimental techniques. Its high affinity and specificity make it a valuable tool for unraveling the complex role of TGFBR2 in cellular processes and disease pathogenesis.
Purified from cell culture supernatant by affinity chromatography
Formulation:
Powder
Buffer:
1XPBS
Storage:
Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing).Lyophilized antibodies are shipped at ambient temperature.
Usage:
Research use only
Background:
The protein encoded by this gene is a transmembrane protein that has a protein kinase domain, forms a heterodimeric complex with TGF-beta receptor type-1, and binds TGF-beta. This receptor/ligand complex phosphorylates proteins, which then enter the nucleus and regulate the transcription of genes related to cell proliferation, cell cycle arrest, wound healing, immunosuppression, and tumorigenesis. Mutations in this gene have been associated with Marfan Syndrome, Loeys-Deitz Aortic Aneurysm Syndrome, and the development of various types of tumors. Alternatively spliced transcript variants encoding different isoforms have been characterized. [provided by RefSeq, Aug 2017]
