The Anti-TFE3 Antibody (CAB7936) is a valuable tool for researchers studying TFE3, a transcription factor involved in various cellular processes, including cell proliferation and differentiation. This antibody, generated in rabbits, is highly specific to TFE3 and has been validated for use in various applications, including Western blot and immunohistochemistry.TFE3 is known to play a critical role in the development and progression of certain cancers, making it an attractive target for therapeutic interventions.
By using the Anti-TFE3 Antibody, researchers can accurately detect and analyze TFE3 expression in different cell types, allowing for a better understanding of its function in both normal and diseased states.Overall, the Anti-TFE3 Antibody is a valuable tool for researchers interested in studying the role of TFE3 in cancer biology and other cellular processes, contributing to advancements in the field of oncology and potentially leading to the development of novel targeted therapies.
Product Name:
TFE3 Rabbit Polyclonal Antibody
SKU:
CAB7936
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-160 of human TFE3 (NP_006512.2).
This gene encodes a basic helix-loop-helix domain-containing transcription factor that binds MUE3-type E-box sequences in the promoter of genes. The encoded protein promotes the expression of genes downstream of transforming growth factor beta (TGF-beta) signaling. This gene may be involved in chromosomal translocations in renal cell carcinomas and other cancers, resulting in the production of fusion proteins. Translocation partners include PRCC (papillary renal cell carcinoma), NONO (non-POU domain containing, octamer-binding), and ASPSCR1 (alveolar soft part sarcoma chromosome region, candidate 1), among other genes. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
7030
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates, using TFE3 antibody (CAB7936) at 1:400 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 30s.
