The Tet2 Polyclonal Antibody (CAB20365) is a valuable tool for researchers studying Tet2, a key enzyme involved in DNA methylation and hematopoiesis regulation. This antibody is produced in rabbits and has been validated for use in Western blot applications, ensuring accurate detection of Tet2 protein levels in human samples.Tet2 is known for its tumor suppressor role in various cancers, as well as its impact on hematopoietic stem cell differentiation and function.
By targeting Tet2, researchers are able to delve into important cellular processes related to cancer development, immune system function, and blood disorders.Overall, the Tet2 Polyclonal Antibody is a reliable reagent for investigating the role of Tet2 in disease pathogenesis and potential therapeutic strategies targeting this enzyme. Its specificity and sensitivity make it a valuable asset for immunology and cancer research studies.
Product Name:
TET2 Rabbit Polyclonal Antibody
SKU:
CAB20365
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 288-448 of mouse TET2 (NP_001035490.2).
Enables methylcytosine dioxygenase activity. Involved in cellular protein modification process; myeloid cell differentiation; and positive regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including DNA demethylation; animal organ development; and hematopoietic stem cell homeostasis. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including brain; extraembryonic component; lower urogenital tract; reproductive system; and urethra epithelium. Human ortholog(s) of this gene implicated in gastrointestinal system cancer (multiple); hematologic cancer (multiple); lung non-small cell carcinoma; and primary immunodeficiency disease. Orthologous to human TET2 (tet methylcytosine dioxygenase 2).
Purification Method:
Affinity purification
Gene ID:
214133
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of extracts of F9 cells, using TET2 antibody (CAB20365) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
