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TET2 Rabbit Polyclonal Antibody (CAB20365)

SKU:
CAB20365
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
Ayu17-44
Ayu17-449
mKIAA1546
E130014J05Rik
€139 - €419
Frequently bought together:

Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:TET2 Rabbit Polyclonal Antibody
SKU:CAB20365
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human,Mouse,Rat
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 288-448 of mouse TET2 (NP_001035490.2).
Sequence:NASK PAIV PGTC PFQK AEHQ QKSA LDIG PSRA ENKT IQGS MELF AEEY YPSS DRNL QASH GSSE QYSK QKET NGAY FRQS SKFP KDSI SPTT VTPP SQSL LAPR LVLQ PPLE GKGA LNDV ALEE HHDY PNRS NRTL LREG KIDH QPKT SSSQ SLNP SVHT P
Tested Applications:WB IF/ICC ELISA
Recommended Dilution:WB,1:500 - 1:1000 IF/ICC,1:50 - 1:200
Synonyms:Ayu17-449; mKIAA1546; E130014J05Rik; TET2
Positive Sample:F9,Rat brain
Conjugate:Unconjugated
Cellular Localization:nucleoplasm, nucleus
Calculated MW:212kDa
Observed MW:280kDa

Enables methylcytosine dioxygenase activity. Involved in cellular protein modification process; myeloid cell differentiation; and positive regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including DNA demethylation; animal organ development; and hematopoietic stem cell homeostasis. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including brain; extraembryonic component; lower urogenital tract; reproductive system; and urethra epithelium. Human ortholog(s) of this gene implicated in gastrointestinal system cancer (multiple); hematologic cancer (multiple); lung non-small cell carcinoma; and primary immunodeficiency disease. Orthologous to human TET2 (tet methylcytosine dioxygenase 2).

Purification Method:Affinity purification
Gene ID:214133
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Product ImageWestern blot analysis of extracts of F9 cells, using TET2 antibody (CAB20365) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.

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