The Anti-TET1 Antibody (CAB20833) is a high-quality research tool designed for the detection and analysis of TET1, a key enzyme involved in DNA demethylation processes. This polyclonal antibody is produced in rabbits and exhibits strong reactivity towards human samples, making it suitable for a variety of applications including Western blotting.TET1, also known as ten-eleven translocation 1, plays a vital role in DNA demethylation by converting 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC). Dysregulation of TET1 has been implicated in various diseases, including cancer and neurological disorders.
Therefore, studying the expression and activity of TET1 using this antibody is essential for research in epigenetics, cancer biology, and gene regulation.With its specificity and sensitivity, the Anti-TET1 Antibody (CAB20833) is a valuable tool for researchers seeking to explore the functions and mechanisms of TET1 in cellular processes and disease pathways. By enabling the detection and analysis of TET1 protein expression, this antibody opens up new possibilities for advancing our understanding of epigenetic regulation and its impact on human health.
Product Name:
TET1 Monoclonal Antibody
SKU:
CAB20833
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1749-1902 of mouse Tet1 (NP_001240786.1).
Enables methylcytosine dioxygenase activity. Involved in several processes, including dendrite morphogenesis; inner cell mass cell differentiation; and protein O-linked glycosylation. Acts upstream of or within DNA demethylation; regulation of DNA methylation; and regulation of genetic imprinting. Located in nucleus. Is expressed in several structures, including brain; early conceptus; embryo ectoderm; lower urogenital tract; and reproductive system. Orthologous to human TET1 (tet methylcytosine dioxygenase 1).
Purification Method:
Affinity purification
Gene ID:
52463
Clone Number:
ARC51466
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3.
Immunohistochemistry analysis of paraffin-embedded human testis using TET1 Rabbit mAb (CAB20833) at dilution of 1:100 (40x lens).Perform high pressure antigen retrieval with 10 mM citrate buffer pH 6.0 before commencing with IHC staining protocol.
